COX-2、Ki-67、Bcl-2、Bax、VEGF和CD105在口腔鳞状细胞癌组织学分级中的免疫组织化学表达

Q4 Medicine Revista Espanola de Patologia Pub Date : 2023-07-01 DOI:10.1016/j.patol.2023.02.005

Enrico Escobar , Fernán Gómez-Valenzuela , Cristian Peñafiel , Alondra Hormazábal-Hevia , Constanza Herrera-Fuentes , Diana Mori-Aliaga

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摘要

口腔鳞状细胞癌（OSCC）是癌症最常见的肿瘤。很少有研究根据OSCC的组织学分级来分析炎症相关蛋白（COX-2）和肿瘤进展的表达。目的根据OSCC组织学分级分析COX-2、Ki-67（细胞增殖）、Bcl-2/Bax（细胞凋亡）、VEGF和CD105（血管生成）的免疫组化表达。材料和方法，对58例OSCC患者的Ki-67、Bcl-2、Bax、VEGF和CD105进行分析。以13例口腔黏膜（OM）为对照。结果COX-2、VEGF、CD105和Ki-67在OSCC中的表达高于OM，特别是在低分化OSCC中（p＜0.05）。Bax在低分化的OSCC中表达较低（p＜0.001），这可能影响临床行为。

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Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma

Introduction

Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck cancer. Few studies have analyzed the expression of proteins related to inflammation (COX-2) and tumor progression according to the histological grade of OSCC.

Objective

Analyze the immunohistochemical expression of COX-2, Ki-67 (cell proliferation), Bcl-2/Bax (apoptosis), VEGF, and CD105 (angiogenesis) according to histological grades of OSCC.

Material and methods

The immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF, and CD105 of 58 cases of OSCC was analyzed. 13 cases of oral mucosa (OM) were analyzed as controls.

Results

COX-2, VEGF, CD105, and Ki-67 were higher in OSCC than in OM, particularly in poorly differentiated OSCC (p < 0.05). Bax expression was lower in poorly differentiated OSCC (p < 0.001). The Bcl-2/Bax ratio was higher in OSCC compared to MO (p < 0.05).