枸杞果实中抗阿尔茨海默病改性Embelin衍生物的分离及硅晶化研究。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2025-01-01 Epub Date: 2023-09-10 DOI:10.1080/14786419.2023.2255920

R Rupesh, R Mohankumar, Sarvesh Sabarathinam

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引用次数: 0

摘要

血栓塞素是存在于血栓塞果中的主要化合物之一。栓塞素具有更广泛的药理活性，如抗炎、抗菌、抗氧化等。这项研究的最终目的是确保减少栓塞对阿尔茨海默病管理的影响。采用还原法分离并修饰了Embelin衍生物(MED)，并通过FT-IR、NMR和质谱技术对其进行了分析。MED分别对接乙酰胆碱酯酶(AChE) β淀粉样蛋白受体PDB ID: 1EVE和1B68。对接得分与阳性标准加兰他明和多奈哌齐相似。

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Isolation and in-silico approach of Modified Embelin derivative from Embelia ribes fruits as anti-Alzheimer agent.

Embelin is one of the primary compounds present in the Embelia ribes fruit. Embelin has a broader pharmacological activity such as Anti-inflammatory, anti-bacterial, antioxidant, and many more. The ultimate aim of the study is to ensure the impact of reduced embelin in the management of Alzheimer's disease. Embelin was isolated and modified by the reduction method, and the Modified Embelin derivative (MED) 3-Undecylcyclohexa-2,5-diene-1,2,4,5-tetraol was analysed through FT-IR, NMR, and Mass Spectroscopic techniques. MED was docked against acetylcholinesterase (AChE) amyloid beta (Aβ) receptors PDB ID: 1EVE & 1B68, respectively. The docking scores remain similar to that of positive standards galantamine and Donepezil.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.