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引用次数: 0
摘要
背景与目的:预处理控制营养状态(CONUT)评分与食管癌患者预后的关系尚不清楚。本荟萃分析的目的是在现有证据的基础上进一步阐明预处理CONUT评分在食管癌预后中的作用。方法:检索截至2022年9月27日的PubMed、Embase、Web of Science和CNKI数据库。主要和次要结局是总生存期(OS)和无进展生存期(PFS)/癌症特异性生存期(CSS)，合并危险比(HR)和95%置信区间(CI)进行分析。结果:共纳入11项回顾性研究，涉及3,783名受试者。合并结果显示，预处理CONUT评分越高，OS越差(HR = 1.82, 95% CI: 1.31-2.54, p < 0.001)，按病理类型分层的亚组分析结果相似。此外，预处理CONUT评分与较差的PFS (HR = 1.19, 95% CI: 1.10-1.28, p < 0.001)和CSS (HR = 2.67, 95% CI: 1.77-4.02, p < 0.001)相关。结论:预处理CONUT评分可预测食管癌预后较差，且CONUT评分高的患者生存期较差。
Prognostic value of pretreatment Controlling Nutritional Status score in esophageal cancer: a meta-analysis.
Background and purpose: The association between the pretreatment Controlling Nutritional Status (CONUT) score and the prognosis of esophageal cancer patients remains unclear. The aim of this meta-analysis was to further elucidate the prognostic role of the pretreatment CONUT score in esophageal cancer based on current evidence. Methods: The PubMed, Embase, Web of Science and CNKI databases were searched up to 27 September 2022. The primary and secondary outcomes were overall survival (OS) and progression-free survival (PFS)/cancer-specific survival (CSS), and the hazard ratio (HR) and 95% confidence interval (CI) were pooled for analysis. Results: A total of 11 retrospective studies involving 3,783 participants were included. The pooled results demonstrated that a higher pretreatment CONUT score was significantly related to poor OS (HR = 1.82, 95% CI: 1.31-2.54, p < 0.001), and subgroup analysis stratified by pathological type showed similar results. In addition, the pretreatment CONUT score was associated with poor PFS (HR = 1.19, 95% CI: 1.10-1.28, p < 0.001) and CSS (HR = 2.67, 95% CI: 1.77-4.02, p < 0.001). Conclusion: The pretreatment CONUT score was predictive of worse prognosis in esophageal cancer, and patients with a higher CONUT score showed worse survival.
期刊介绍：
Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.
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