Dumon支架治疗良性气道狭窄的长期疗效和安全性。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2023-01-01 DOI:10.1177/17534666231181269
Li-Qin Lin, Di-Fei Chen, Hong-Kai Wu, Yu Chen, Chang-Hao Zhong, Xiao-Bo Chen, Chun-Li Tang, Zi-Qing Zhou, Shi-Yue Li
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摘要

背景:Dumon支架治疗良性气道狭窄的长期疗效尚不清楚。目的:本研究的目的是评估Dumon支架在良性气道狭窄患者中的长期疗效和安全性。方法:回顾性分析2014年3月至2021年10月在广州医科大学第一附属医院接受Dumon支架治疗的良性气道狭窄患者。我们纳入了植入硅胶支架后成功取出的患者。收集和分析支气管镜介入手术及相关并发症的临床资料和信息。结果:纳入99例良性气道狭窄患者。支架主要放置在气管(44.4%)和左主支气管(43.4%)。狭窄类型以结核后支气管狭窄为主(57.6%)。总治愈率为60.6%。支架相关并发症包括分泌物潴留(70.7%)、肉芽肿形成(67.7%)、支架成角(21.2%)和支架移位(12.1%)。支架治疗左主支气管狭窄效果较差(p = 0.012)。多因素logistic回归分析发现,支架放置超过13个月,支架干预次数≥1预示着良好的结果。结论:Dumon支架治疗良性气道狭窄的疗效和安全性有待提高。支架治疗左主支气管狭窄效果较差;在这种情况下,需要定期随访。支架放置> 13个月和6个月内不超过一次支架干预与良好的结果相关。
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Long-term efficacy and safety of the Dumon stent for treatment of benign airway stenosis.

Background: The long-term efficacy of the Dumon stent in the treatment of benign airway stenosis is unclear.

Objective: The objective of this study was to evaluate the long-term efficacy and safety of the Dumon stent in patients with benign airway stenosis.

Methods: We retrospectively reviewed patients with benign airway stenosis who were treated with a Dumon stent at the First Affiliated Hospital of Guangzhou Medical University between March 2014 and October 2021. We included patients with successful removal of silicone stents after implantation. The clinical data and information on bronchoscopic interventional procedures and related complications were collected and analyzed.

Results: Ninety-nine patients with benign airway stenosis were included. The stent was placed mainly in the trachea (44.4%) and left main bronchus (43.4%). The main type of stenosis was post-tuberculosis bronchial stenosis (57.6%). The overall cure rate was 60.6%. Stent-related complications included retention of secretions (70.7%), granuloma formation (67.7%), stent angulation (21.2%), and stent migration (12.1%). The stent was less effective for left main bronchus stenosis (p = 0.012). Multivariate logistic regression analysis identified that stent placement for more than 13 months, a stent-intervention number of ⩽ 1 predicted a favorable outcome.

Conclusion: The efficacy and safety of the Dumon stent for benign airway stenosis need improvement. The stent is less effective for left main bronchus stenosis; regular follow-up is required in such cases. Stent placement for > 13 months and no more than once stent intervention within a 6-month period were associated with a favorable outcome.

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