慢性膝关节疼痛患者体内维生素 D 代谢基因的甲基化程度不同

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2023-01-01 Epub Date: 2023-02-28 DOI:10.1159/000529823
Larissa J Strath, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C Foster, Roger B Fillingim, Yenisel Cruz-Almeida
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引用次数: 0

摘要

简介最近的证据表明,维生素 D 可能与表观基因组相互作用,并在疼痛体验中发挥作用。为了使维生素 D 发挥正常作用,必须有足够水平的维生素 D 存在,并通过酶促反应使维生素 D 具有生物活性。本研究的目的是探索慢性膝关节疼痛患者和非慢性膝关节疼痛患者体内参与维生素 D 代谢的基因的表观遗传结构:作为一项以膝关节疼痛为重点的大型研究的一部分,该研究招募了社区居民,他们提供了人口统计学、临床和疼痛相关信息,并提供了静脉血液样本以测定 CpG 位点的 DNA 甲基化水平:结果发现:在编码维生素 D 代谢相关酶的基因中,有疼痛和无疼痛患者的 DNA 甲基化水平存在差异:CYP27B1(1-α-羟化酶)。此外,编码维生素 D 受体(VDR)的基因也存在高甲基化现象:结论:慢性疼痛的存在与负责维生素 D 代谢和细胞功能相关酶表达的基因的表观遗传学改变有关。这些结果为了解维生素 D 与慢性疼痛之间的关联机制奠定了基础。
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Vitamin D Metabolism Genes Are Differentially Methylated in Individuals with Chronic Knee Pain.

Introduction: Recent evidence suggests that vitamin D may interact with the epigenome and play a role in the pain experience. In order for proper functioning to occur, there must be an adequate level of vitamin D present, made possible by enzymatic reactions that allow vitamin D to be biologically active. The purpose of this study was to explore the epigenetic landscape of genes involved in vitamin D metabolism in individuals with and without chronic knee pain.

Methods: Community-dwelling individuals recruited as part of a larger study focused on knee pain provided demographic, clinical, and pain-related information, as well as an intravenous blood sample to determine DNA methylation levels at CpG sites.

Results: There were differences in DNA methylation between those with and without pain in genes that code for enzymes related to vitamin D metabolism: CYP27B1 (1-α-hydroxylase). There was also hypermethylation on the gene that codes for the vitamin D receptor (VDR).

Conclusions: The presence of chronic pain is associated with epigenetic modifications in genes responsible for the expression of enzymes involved in vitamin D metabolism and cellular function. These results lay groundwork in understanding the mechanism underlying the association between vitamin D and chronic pain.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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