翻译机器在运动。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-09-01 Epub Date: 2023-05-03 DOI:10.1002/wrna.1792
Hassan Zafar, Ahmed H Hassan, Gabriel Demo
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引用次数: 0

摘要

翻译的准确性是蛋白质合成的最关键因素之一。它受核糖体及其动态行为的调节,以及指导核糖体重排的翻译因子,使翻译成为一个统一的过程。早期对具有停滞翻译因子的核糖体复合体的结构研究为理解核糖体动力学及其翻译过程奠定了基础。时间分辨和系综冷冻电镜的最新技术进步使以高分辨率实时研究翻译成为可能。这些方法提供了细菌中所有三个阶段的翻译的详细视图:起始、延伸和终止。在这篇综述中,我们关注翻译因子(在某些情况下GTP激活)及其监测和响应核糖体组织的能力,以实现高效准确的翻译。本文分类在:翻译>核糖体结构/功能翻译>机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Translation machinery captured in motion.

Translation accuracy is one of the most critical factors for protein synthesis. It is regulated by the ribosome and its dynamic behavior, along with translation factors that direct ribosome rearrangements to make translation a uniform process. Earlier structural studies of the ribosome complex with arrested translation factors laid the foundation for an understanding of ribosome dynamics and the translation process as such. Recent technological advances in time-resolved and ensemble cryo-EM have made it possible to study translation in real time at high resolution. These methods provided a detailed view of translation in bacteria for all three phases: initiation, elongation, and termination. In this review, we focus on translation factors (in some cases GTP activation) and their ability to monitor and respond to ribosome organization to enable efficient and accurate translation. This article is categorized under: Translation > Ribosome Structure/Function Translation > Mechanisms.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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