白质高信号联合血清NLRP3对脑血管病患者认知功能障碍的诊断价值

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2023-11-01 Epub Date: 2023-09-13 DOI:10.1080/00365513.2023.2255974
Ronghui Huang, Lin Zhang, Limeng Deng, Can Chen
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引用次数: 0

摘要

背景:白质高信号(WMH)被广泛用于脑小血管疾病(CSVD)的诊断。然而,NLRP3是否与CSVD后认知障碍相关尚不清楚。目的:探讨WMHs联合NLRP3对CSVD后认知功能障碍的诊断价值。方法:这项前瞻性观察性研究于2019年9月至2022年5月共纳入188例CSVD患者。所有患者均接受脑MRI评估,并记录WMH Fazekas评分和WMH体积。ELISA法检测血清NLRP3水平。诊断CSVD 6个月后,用MoCA测定患者的认知功能。记录血清C反应蛋白(CRP)、白细胞介素(IL)-6、总胆固醇(TC)、甘油三酯(TG)、高密度瘦素胆固醇(HDL)和低密度瘦素胆固醇(LDL)水平。结果:认知功能障碍CSVD患者Fazekas评分、WMH体积、血清NLRP3和IL-6水平显著高于无认知功能障碍患者。Fazekas评分与WMH体积、NLRP3水平呈正相关。结合WMH体积和NLRP3对认知功能障碍的诊断具有更好的特异性。冠状动脉综合征史、WMH体积和NLRP3是CSVD后认知功能障碍的独立危险因素。结论:Fazekas评分、WMH体积和血清NLRP3水平与CSVD后认知功能障碍相关,具有作为诊断性生物标志物的潜力。
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White matter hyperintensities combined with serum NLRP3 in diagnosis of cognitive impairment in patients with cerebral small vessel disease.

Background: White matter hyperintensities (WMH) are widely used for the diagnosis of cerebral small vessel disease (CSVD). However, whether NLRP3 is correlated with cognitive impairment after CSVD is still not clear.Objective: This study aimed to investigate the diagnostic value of WMHs combined with NLRP3 for cognitive impairment after CSVD.Methods: This prospective observational study enrolled a total of 188 CSVD patients from September 2019 to May 2022. All patients received brain MRI assessment and WMH Fazekas score, as well as WMH volume, was recorded. Serum NLRP3 level was measured by ELISA. Patients' cognitive function was measured by MoCA after 6 months of diagnosis of CSVD. The serum levels of C reactive protein (CRP), interleukin (IL)-6, total cholesterol (TC), triglyceride (TG), high-density leptin cholesterol (HDL) and low-density leptin cholesterol (LDL) were recordedResults: CSVD patients with cognitive impairment had significantly higher Fazekas scores, WMH volumes, serum NLRP3 and IL-6 levels compared to patients without cognitive impairment. A positive correlation was found among Fazekas scores, WMH volumes and NLRP3 levels. The combination of WMH volume and NLRP3 could achieve a better specificity for the diagnosis of cognitive impairment. Coronary syndrome history, WMH volume and NLRP3 were found as independent risk factors for cognitive impairment after CSVD.Conclusion: Fazekas scores, WMH volume and serum NLRP3 levels are associated with cognitive impairment after CSVD and have the potential to be used as diagnostic biomarkers.

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来源期刊
CiteScore
3.50
自引率
4.80%
发文量
85
审稿时长
4-8 weeks
期刊介绍: The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.
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