Spotlight on Three Rs Progress.

The FRAME Innovation Grant funding stream provides small grants for studies that will support the replacement of animals in biomedical research. FRAME launched the annual Innovation Grant scheme in 2021 to address a gap in the availability of small funding pots for proof-of-principle research and pilot projects. The scheme offers grants of around £5000, but will consider applications asking for up to £15,000. Projects should last between six months and two years. The first two years of this scheme proved to be very popular and resulted in the funding of some diverse and interesting projects. The grants represent a pilot project funding stream, to enable scientists to explore innovative ideas, methods and techniques and, where relevant, to generate proof-ofprinciple data to support applications for larger grants in the future. All applications for funding will be assessed by a panel of academics, FRAME staff and, where possible, an expert in the relevant field, according to the following key criteria: