{"title":"\"关于我死亡的报道被严重夸大了\":后基因组时代的行为遗传学》。","authors":"K Paige Harden","doi":"10.1146/annurev-psych-052220-103822","DOIUrl":null,"url":null,"abstract":"<p><p>Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.</p>","PeriodicalId":8010,"journal":{"name":"Annual review of psychology","volume":"72 ","pages":"37-60"},"PeriodicalIF":23.6000,"publicationDate":"2021-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372814/pdf/nihms-1908424.pdf","citationCount":"0","resultStr":"{\"title\":\"\\\"Reports of My Death Were Greatly Exaggerated\\\": Behavior Genetics in the Postgenomic Era.\",\"authors\":\"K Paige Harden\",\"doi\":\"10.1146/annurev-psych-052220-103822\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.</p>\",\"PeriodicalId\":8010,\"journal\":{\"name\":\"Annual review of psychology\",\"volume\":\"72 \",\"pages\":\"37-60\"},\"PeriodicalIF\":23.6000,\"publicationDate\":\"2021-01-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372814/pdf/nihms-1908424.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual review of psychology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-psych-052220-103822\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/9/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of psychology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1146/annurev-psych-052220-103822","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/9/8 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
行为遗传学研究人与人之间的基因差异是如何导致其心理和行为差异的。在此,我将介绍在可以直接测量人类基因组的后基因组时代,行为遗传学的结论和方法是如何演变的。首先,我重温了行为遗传学的第一定律,即万物皆可遗传,并介绍了对双胞胎数据进行大规模荟萃分析的结果,以及利用测定的 DNA 估算遗传率的新方法。其次,我将介绍统计遗传学的新方法,包括全基因组关联研究和多基因评分分析。第三,我将介绍基因与环境相互作用方面的新一代研究成果,特别关注遗传影响因素如何在不同的社会政治背景和外源环境中发生变化。基因组技术带来了一个新工具的黄金时代,以解决有关基因和环境如何结合创造人类独特生活的永恒问题。
"Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era.
Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.
期刊介绍:
The Annual Review of Psychology, a publication that has been available since 1950, provides comprehensive coverage of the latest advancements in psychological research. It encompasses a wide range of topics, including the biological underpinnings of human behavior, the intricacies of our senses and perception, the functioning of the mind, animal behavior and learning, human development, psychopathology, clinical and counseling psychology, social psychology, personality, environmental psychology, community psychology, and much more. In a recent development, the current volume of this esteemed journal has transitioned from a subscription-based model to an open access format as part of the Annual Reviews' Subscribe to Open initiative. As a result, all articles published in this volume are now freely accessible to the public under a Creative Commons Attribution (CC BY) license.