编码过程中的情绪调节减少了抑郁症状患者的负面记忆,增强了中性记忆辨别能力

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2023-09-04 DOI:10.1016/j.nlm.2023.107824
Brandon K. Hayes, Amritha Harikumar, Lorena A. Ferguson, Eva E. Dicker, Bryan T. Denny, Stephanie L. Leal
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引用次数: 0

摘要

抑郁症患者表现出情绪调节功能失调、普遍的情景记忆缺陷和消极偏见,消极经历会被更好地记住。最近的研究表明,抑郁症中的消极偏见可能是由增强的记忆辨别驱动的,记忆辨别是一种依赖于海马模式分离的记忆测量方法,这种计算方法将具有重叠特征的经历处理为独特的。以前,我们发现有抑郁症状的人表现出更强的负面和受损的中性助记符辨别能力。目前的研究旨在研究情绪调节作为一种改变抑郁症状患者负面和中性事件记忆编码的方法。在这里,我们发现,在编码过程中应用心理距离(一种认知重新评估策略,其特征是对负面事件采取第三人称视角)与抑郁症患者在检索过程中减少负面和增强中性助记符歧视有关。这些结果表明,在编码过程中应用情绪调节技术可能为改变抑郁症状患者的功能障碍记忆提供一种有效的方法。鉴于药物治疗往往无法治疗抑郁症,情绪调节为改变认知和情绪过程提供了一种强大而实用的方法。未来的神经影像学研究对于确定情绪调节如何影响这些发现背后的神经机制至关重要。
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Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms

Individuals with depression exhibit dysfunctional emotion regulation, general episodic memory deficits, and a negativity bias, where negative experiences are better remembered. Recent work suggests that the negativity bias in depression may be driven by enhanced mnemonic discrimination, a memory measure that relies on hippocampal pattern separation – a computation that processes experiences with overlapping features as unique. Previously, we found that individuals with depressive symptoms show enhanced negative and impaired neutral mnemonic discrimination. The current study aimed to investigate emotion regulation as an approach toward modifying memory encoding of negative and neutral events in individuals with depressive symptoms. Here we show that applying psychological distancing (a cognitive reappraisal strategy characterized by taking a third-person perspective toward negative events) during encoding was associated with reduced negative and enhanced neutral mnemonic discrimination during retrieval in individuals with depressive symptoms. These results suggest that applying emotion regulation techniques during encoding may provide an effective approach toward altering dysfunctional memory in those with depressive symptoms. Given that pharmacological treatments often fail to treat depression, emotion regulation provides a powerful and practical approach toward modifying cognitive and emotional processes. Future neuroimaging studies will be important to determine how emotion regulation impacts the neural mechanisms underlying these findings.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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