世界卫生组织2010年十年:精子总数的时间趋势和生活方式因素的作用。

IF 3 2区 医学 Q2 ANDROLOGY Asian Journal of Andrology Pub Date : 2023-09-01 Epub Date: 2023-01-17 DOI:10.4103/aja202297
Francesco Cargnelutti, Francesco Pallotti, Tania Carlini, Fabiana Faja, Anna Rita Vestri, Danilo Alunni Fegatelli, Andrea Lenzi, Francesco Lombardo, Donatella Paoli
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引用次数: 0

摘要

据报道,1938年至1991年间,精子浓度大幅下降,许多研究人员调查了人类精子质量恶化的可能性。尽管付出了巨大的努力,公布的证据仍然存在争议。同样,生活方式因素对精液参数的作用也存在争议。我们在意大利进行了一项单中心研究,以评估过去10年(2010年至2019年)的精子总数趋势。此外,我们评估了生活方式因素与精子总数之间的关系,以确定可能的损害因素。我们进行了一项回顾性研究,分析了2010年至2019年间进行精液分析的18-55岁受试者。共有3329名受试者被纳入:1655名因特发性不孕被转诊至我院(意大利罗马萨皮恩扎大学实验医学系)的受试者,1674名因未确诊男科疾病而被转诊进行孕前或男科筛查的受试人。根据世界卫生组织(世界卫生组织)2010年的标准,由两名受过相同训练和使用相同设备的神学家对精液样本进行检查。在统计评估中,只考虑精子总数(每次射精×106)。在过去十年中,我们在整个人群或两个亚组(不孕组和对照组)中没有发现平均精子总数的显著变化。在一项多变量分析中,精子总数与不孕史、体重指数(BMI)和吸烟显著相关。我们的研究结果表明,不育男性是“脆弱”的受试者,特别容易受到几个负面因素的影响,其中许多因素仍然未知。我们的研究强调了对男性生活方式进行研究的必要性,以发现并减少有害因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A decade of WHO 2010: total sperm number temporal trend and role of lifestyle factors.

After a huge decline in sperm concentration between 1938 and 1991 was reported, many researchers investigated the possibility of a worsening of human sperm quality. Despite massive efforts, published evidence is still controversial. Similarly, the role of lifestyle factors on semen parameters is debated. We conducted a monocentric Italian study to evaluate the total sperm number trend over the last 10 years (from 2010 to 2019). Additionally, we evaluated the association between lifestyle factors and total sperm number in order to identify possible damaging factors. We performed a retrospective study analyzing subjects aged 18-55 years who had their semen analyzed between 2010 and 2019. A total of 3329 subjects were included: 1655 subjects referred to our department (Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy) for idiopathic infertility and 1674 subjects referred for preconceptional or andrological screening with no confirmed andrological diseases. Semen samples were examined according to World Health Organization (WHO) 2010 criteria by two seminologists with the same training and the same equipment. For statistical evaluations, only total sperm number (×10 6 per ejaculate) was taken into consideration. We detected no significant changes in mean total sperm number during the last decade, in either the entire population or the two subgroups (infertile group and control group). In a multivariate analysis total sperm number was significantly associated with the history of infertility, body mass index (BMI) and cigarette smoking. Our results suggest that infertile men are "vulnerable" subjects, particularly susceptible to several negative factors, many of which still remain unknown. Our study highlights the need for studies addressing men's lifestyle in order to find and reduce deleterious agents.

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来源期刊
Asian Journal of Andrology
Asian Journal of Andrology 医学-泌尿学与肾脏学
CiteScore
4.90
自引率
3.40%
发文量
2252
审稿时长
2.2 months
期刊介绍: Fields of particular interest to the journal include, but are not limited to: -Sperm biology: cellular and molecular mechanisms- Male reproductive system: structure and function- Hormonal regulation of male reproduction- Male infertility: etiology, pathogenesis, diagnosis, treatment and prevention- Semen analysis & sperm functional assays- Sperm selection & quality and ART outcomes- Male sexual dysfunction- Male puberty development- Male ageing- Prostate diseases- Operational andrology- HIV & male reproductive tract infection- Male contraception- Environmental, lifestyle, genetic factors and male health- Male reproductive toxicology- Male sexual and reproductive health.
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