豆蔻叶对丙硫尿嘧啶致甲状腺功能减退雄性BALB/c小鼠激素变化及精子发生的影响

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM Endocrinology, Diabetes and Metabolism Pub Date : 2023-07-04 DOI:10.1002/edm2.438

Bahar Atabaki, Naser Mirazi, Abdolkarim Hosseini, Abdolrahman Sarihi, Zahra Izadi, Alireza Nourian

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摘要

精子发生受甲状腺的显著影响。甲状腺疾病可由多种因素引起。传统上，小豆蔻被用来治疗各种疾病。研究了豆蔻提取物(ECE)对甲状腺功能减退小鼠精子发生的影响。方法选取体重(25 ~ 35 g)的雄性小鼠42只，随机分为6组:对照组(生理盐水，0.5 mL/d，灌胃[P.O.])、甲状腺功能减退组(0.1%丙硫脲嘧啶饮水2周)、左甲状腺素治疗组(15 mg/kg/d, P.O.)和ECE治疗组(100、200、400 mg/kg/d, P.O.)。实验结束后，对小鼠进行麻醉，并采集血液样本进行激素分析。结果对睾丸进行了精子计数和显微检查。结果显示，与对照组相比，甲状腺功能减退动物的T3、T4、睾酮水平和精子发生均下降，促甲状腺激素、促卵泡激素和黄体生成素均升高。与甲状腺功能减退组相比，ECE治疗逆转了这些作用。结论ECE可刺激甲状腺功能，增加睾酮和精子发生。

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Effect of Elettaria cardamomum L. on hormonal changes and spermatogenesis in the propylthiouracil-induced hypothyroidism male BALB/c mice

Introduction

Spermatogenesis is significantly influenced by the thyroid gland. Thyroid disorders can be caused by a variety of factors. Traditionally, Ellettaria cardamomum has been used to treat a variety of ailments. The effects of E. cardamomum extract (ECE) on spermatogenesis in hypothyroid mice were investigated in this study.

Methods

In this study 42 male mice, weighing (25–35 g) were randomly divided in six groups: control group (taking normal saline, 0.5 mL/day, by oral gavage [P.O.]), hypothyroid group (taking 0.1% propylthiouracil in drinking water for 2 weeks), hypothyroid groups treated by levothyroxine (15 mg/kg/day, P.O.) and hypothyroid groups treated by ECE (100, 200 and 400 mg/kg/day, P.O.). After the end of experiments the mice were anaesthetised and blood samples were collected for hormonal analysis.

Results

The sperm count and microscopic studies of testes were done also. Our results showed that the T₃, T₄, testosterone levels and spermatogenesis in hypothyroid animals decreased and thyroid-stimulating hormone, follicle-stimulating hormone and luteinizing hormone increased compared with control group. Treatment by ECE reverse these effects in comparison with hypothyroid group.