实践改变:在肌浸润性膀胱癌症患者中,扩大淋巴结切除术在根治性膀胱切除术中没有益处。

IF 3 3区 医学 Q2 ONCOLOGY Seminars in oncology Pub Date : 2023-06-01 DOI:10.1053/j.seminoncol.2023.09.001
Omar Fahmy , Maxim Kochergin , Anastasios D. Asimakopoulos , Georgios Gakis
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引用次数: 0

摘要

几十年来,对于肌侵犯性膀胱癌症患者,扩大盆腔淋巴结清扫一直是根治性膀胱切除术中不可或缺的一部分。这种做法是基于大型回顾性荟萃分析,表明扩大解剖对肿瘤学有益。这篇小型综述和荟萃分析包括了当前文献中可用的两项随机试验。因此,它可以被认为是关于扩大盆腔淋巴结切除术预后益处的最强证据。根据目前的随机数据,标准的盆腔淋巴结清扫达到髂分叉水平就足够了,并且将清扫范围扩大到该水平以上并不能提供任何额外的肿瘤学益处。
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Practice change: No benefit of extended lymphadenectomy at radical cystectomy in patients with muscle invasive bladder cancer

For many decades, extended pelvic lymph node dissection has been an integral part during radical cystectomy for patients with muscle invasive bladder cancer. This practice was based on large retrospective meta-analyses suggesting an oncologic benefit to an extended dissection. This mini review and meta-analysis includes the two available randomized trials in the current literature. Therefore, it can be considered as the strongest level of evidence regarding the prognostic benefit of an extended pelvic lymphadenectomy. Based on current randomized data, standard pelvic lymph node dissection up to the level of iliac bifurcation is sufficient, and extension of the dissection above this level does not provide any additional oncologic benefit.

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来源期刊
Seminars in oncology
Seminars in oncology 医学-肿瘤学
CiteScore
6.60
自引率
0.00%
发文量
58
审稿时长
104 days
期刊介绍: Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.
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