富血小板纤维蛋白对第三磨牙拔除后骨修复的评价——随机临床试验。

E-D-R Rodrigues, A-D Pontual, R-A Macedo, E Nascimento, B-C Vasconcelos
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引用次数: 0

摘要

背景:本研究的目的是评估富血小板纤维蛋白(PRF)对阻生第三磨牙拔牙后伤口和骨愈合、疼痛、肿胀和牙周并发症的影响。材料与方法:采用前瞻性、随机、裂口双盲临床试验。在拔牙后和粘膜瓣缝合前将PRF放置在牙槽内,对照组牙槽不做任何处理。根据术后90天内获得的骨体积对患者进行评估。其他变量包括小梁厚度、小梁距离和灰色值、疼痛、肿胀和伤口愈合。在5%显著性水平下采用Wilcoxon检验和t-Student检验,多重比较采用Friedman检验。结果:本组共手术44例。患者平均年龄22.41岁(±2.75岁),72.73%为女性。PRF与骨小梁厚度和骨体积平均值增加相关(p < 0.001)。实验组在4h、6h、8h、16h、24h、72h疼痛评分明显低于对照组(p小于0.05)。实验组的平均肿胀较低(p < 0.001)。PRF组创面愈合显著提高(p小于0.001)。结论:PRF充填牙槽能促进拔牙后伤口和骨愈合,同时减少术后疼痛和肿胀。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Evaluation of bone repair with platelet-rich fibrin following the extraction of impacted third molars - randomized clinical trial.

Background: The aim of the present study was to evaluate postoperative effects of platelet-rich fibrin (PRF) in wound and bone healing, pain, swelling and periodontal complications outcomes after impacted third molars extraction.

Material and methods: A prospective, randomized, split-mouth, double-blind clinical trial was conducted. PRF was placed within sockets following tooth removal and before suturing mucoperiosteal flap while no treatment was performed on control group's sockets. Patients were evaluated considering bone volume which was obtained in the 90-day postoperative period. Other variables included trabecular thickness, trabecular distance and grey values, pain, swelling, and wound healing. A Wilcoxon test and a t-Student test were used at a 5% significance level and a Friedman test was used to multiple comparisons.

Results: Forty-four surgeries were performed in the present study. The patients' mean age was 22.41 (± 2.75 years) and 72.73% were women. PRF was associated to increased trabecular thickness and bone volume means (p < 0.001). The experimental group had significantly lower pain scores at 4h, 6h, 8h, 16h, 24h, and 72h (p ˂ 0.05). Mean swelling was lower on the experimental group (p < 0.001). The PRF group showed significant higher wound healing (p ˂ 0.001).

Conclusions: Alveolar filling with PRF improves wound and bone healing after extractions while also decreasing pain and swelling in the postoperative period.

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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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