免疫检查点抑制剂时代骨转移非小细胞肺癌癌症患者的骨改性剂：叙述性综述。

IF 3 3区医学 Q2 ONCOLOGY Seminars in oncology Pub Date : 2023-06-01 DOI:10.1053/j.seminoncol.2023.09.002

Jinyoung Kim , Chaiho Jeong , Jeongmin Lee , Jeonghoon Ha , Ki-Hyun Baek , Seohyun Kim , Tai Joon An , Chan Kwon Park , Hyoung Kyu Yoon , Jeong Uk Lim

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引用次数: 0

摘要

在癌症进展过程中，约40%的患者发生骨转移。癌症患者骨转移的常见并发症包括肌肉骨骼疼痛、病理性骨折、脊髓压迫和高钙血症。我们讨论了骨改性剂（BMAs）在减少骨相关事件（SRE）和改善癌症相关结果方面的疗效，特别是在IV期非小细胞肺癌癌症骨转移患者中。此外，还探讨了BMA与放疗或免疫疗法在减少癌症和骨转移患者SRE方面的联合作用。

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Bone-modifying agents for non–small-cell lung cancer patients with bone metastases during the era of immune checkpoint inhibitors: A narrative review

During the course of lung cancer progression, bone metastases occur in about 40% of patients. Common complications associated with bone metastases in lung cancer patients include musculoskeletal pain, pathologic fractures, spinal cord compression, and hypercalcemia. We discuss the efficacy of bone-modifying agents (BMAs) in reducing skeletal-related events (SREs) and improving cancer-related outcomes, particularly in patients with stage IV non–small-cell lung cancer with bone metastases. In addition, the combined effects of BMAs with radiotherapy or immunotherapy in reducing SREs in patients with lung cancer and bone metastases are explored.

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来源期刊

Seminars in oncology 医学-肿瘤学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

104 days

期刊介绍： Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.