胃肠道间质瘤49例复发及生存分析

Nuray Colapkulu-Akgul, Humeyra Gunel, Damla Beyazadam, Mehmet S Ozsoy, Orhan Alimoglu
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引用次数: 0

摘要

背景:胃肠道间质瘤(gist)是最常见的起源于胃肠道的间质肿瘤,具有广泛的临床病理特征,影响疾病管理和治疗方式。方法:回顾性分析2008 - 2016年间49例胃肠肿瘤手术患者。统计分析复发和不复发患者的临床、病理和免疫组织化学特征。结果:29例(59.1%)患者有胃;16例(32.6%)有小肠;3例(6.1%)为肠系膜;1例(2.2%)有直肠胃肠道间质瘤。镜下肿瘤坏死和肿瘤溃疡对疾病复发也有显著意义(P = 0.005, P = 0.049)。根据Miettinen风险分类,高危患者更容易复发(P P P = 0.044)。结论:肿瘤越大,有丝分裂率越高,复发的可能性越大。高Ki-67水平也与复发有关。
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Gastrointestinal Stromal Tumors: Recurrence and Survival Analysis of 49 Patients.

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor originating from the gastrointestinal tract and have a broad spectrum of clinicopathological features affecting disease management regarding the treatment modalities. Methods: A retrospective study of 49 patients who underwent surgery for gastrointestinal tumors between 2008 and 2016 was conducted. Clinical, pathological, and immunohistochemical features of patients with and without recurrence were statistically analyzed. Results: Twenty-nine (59.1%) patients had gastric; 16 (32.6%) had small intestinal; 3 (6.1%) had mesenteric; and 1 (2.2%) had rectal GISTs. Microscopic tumor necrosis and tumor ulceration were also significant for disease recurrence (P = 0.005, P = 0.049). High-risk patients according to Miettinen's risk classification were more likely to develop a recurrence (P < 0.001). Additionally, high-grade tumors were also a risk factor for recurrence (P < 0.001). Ki-67 levels were available in 40 patients and the mean Ki-67 level was 16.8 in patients with recurrence, which was a significant risk factor in regression analysis (HR: 1.24, 95%, CI: 1.08-1-43). Five-year disease-free survival rates of non-gastric and gastric GISTs were 62.3% and 90%, respectively (P = 0.044). Conclusion: Larger tumors and higher mitotic rates are more likely to develop recurrence. High Ki-67 levels were also associated with recurrence.

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来源期刊
Middle East Journal of Digestive Diseases
Middle East Journal of Digestive Diseases Medicine-Gastroenterology
CiteScore
1.20
自引率
0.00%
发文量
33
审稿时长
12 weeks
期刊最新文献
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