基于磁共振技术的皮质内血管可视化和特征描述:了解微血管疾病对骨骼健康的影响。

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Current Opinion in Endocrinology & Diabetes and Obesity Pub Date : 2023-08-01 Epub Date: 2023-06-19 DOI:10.1097/MED.0000000000000819
Maximilian T Löffler, Po-Hung Wu, Galateia J Kazakia
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引用次数: 0

摘要

综述的目的:人们对骨血管与骨微结构和强度之间的关系仍不完全了解。要填补这一空白,就必须具备活体成像能力。我们描述了密实骨的相关血管解剖结构,回顾了目前基于磁共振成像(MRI)的可在体内评估皮质内血管的技术,最后介绍了应用这些技术研究皮质内血管在衰老和疾病中变化的初步研究:超短回波时间磁共振成像(UTE MRI)、动态对比增强磁共振成像(DCE-MRI)和感度加权磁共振成像技术能够探测皮层内血管。将 DCE-MRI 应用于 2 型糖尿病患者时,与非糖尿病对照组相比,能发现明显更大的皮质内血管。使用同样的技术,与没有微血管疾病的患者相比,在微血管疾病患者身上观察到的较小血管数量明显增多。灌注核磁共振成像的初步数据显示,随着年龄的增长,皮质灌注减少。总结:开发体内皮质内血管可视化和特征描述技术将有助于探索血管和骨骼系统之间的相互作用,并进一步了解皮质孔扩张的驱动因素。随着我们对皮质孔扩张潜在途径的研究,适当的治疗和预防策略也将得到明确。
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MR-based techniques for intracortical vessel visualization and characterization: understanding the impact of microvascular disease on skeletal health.

Purpose of review: The relationships between bone vasculature and bone microstructure and strength remain incompletely understood. Addressing this gap will require in vivo imaging capabilities. We describe the relevant vascular anatomy of compact bone, review current magnetic resonance imaging (MRI)-based techniques that allow in vivo assessment of intracortical vasculature, and finally present preliminary studies that apply these techniques to investigate changes in intracortical vessels in aging and disease.

Recent findings: Ultra-short echo time MRI (UTE MRI), dynamic contrast-enhanced MRI (DCE-MRI), and susceptibility-weighted MRI techniques are able to probe intracortical vasculature. Applied to patients with type 2 diabetes, DCE-MRI was able to find significantly larger intracortical vessels compared to nondiabetic controls. Using the same technique, a significantly larger number of smaller vessels was observed in patients with microvascular disease compared to those without. Preliminary data on perfusion MRI showed decreased cortical perfusion with age.

Summary: Development of in vivo techniques for intracortical vessel visualization and characterization will enable the exploration of interactions between the vascular and skeletal systems, and further our understanding of drivers of cortical pore expansion. As we investigate potential pathways of cortical pore expansion, appropriate treatment and prevention strategies will be clarified.

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来源期刊
CiteScore
5.80
自引率
3.10%
发文量
128
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Endocrinology, Diabetes and Obesity delivers a broad-based perspective on the most recent and exciting developments in the field from across the world. Published bimonthly and featuring twelve key topics – including androgens, gastrointestinal hormones, diabetes and the endocrine pancreas, and neuroendocrinology – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.
期刊最新文献
Precision medicine in diabetes care. Type 2 diabetes: a contemporary view from the Asian lens. Interactions between antidiabetes medications and heart-brain axis. Diabetes agents taking centre stage, playing to the beats of Canon in D. Editorial introductions.
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