单管8色流式细胞术分析的最小残留疾病与成人B细胞急性淋巴细胞白血病临床结果的相关性:一项基于486名患者的真实世界研究。

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY Archives of pathology & laboratory medicine Pub Date : 2023-10-01 DOI:10.5858/arpa.2022-0172-OA
Hongyan Liao, Nenggang Jiang, Ying Yang, Xin Zhang, Jiao Chen, Hongli Lai, Qin Zheng
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引用次数: 0

摘要

上下文。--:通过分子和多参数流式细胞术(MFC)测量的最小/可测量残留疾病(MRD)已被证明可以预测B细胞急性淋巴细胞白血病(B-ALL)患者的复发和生存。一种低成本但不影响成人B-ALL预后预测的灵敏度和能力的普遍适用的抗体组仍未建立。目标。--:报告我们使用单管8色MFC面板测量MRD状态作为成人B-ALL患者预后指标的经验。设计。--:我们基于10年内486名患者的大型现实世界队列,回顾性分析了成人B-ALL的特征、MRD状态和预后。结果。--:通过MFC和聚合酶链式反应(PCR)分析对BCR-ABL+患者进行的MRD评估显示,74.2%的病例的结果一致。我们的MFC小组的MRD-状态可以清楚地预测诱导结束时和1个巩固疗程结束时良好的无复发生存率(RFS)和总生存率(OS)。与分别具有至少1个MRD+结果和连续MRD+的患者相比,具有连续MRD-结果和至少1个MRD-结果的患者显示出良好的RFS和OS。结论。--:单管8色MFC面板显示出低成本、良好的灵敏度和与聚合酶链式反应MRD的可比性,但在预测RFS和OS方面表现出色,因此可以作为评估成人B-ALL患者治疗反应的常规指标。
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Association of Minimal Residual Disease by a Single-Tube 8-Color Flow Cytometric Analysis With Clinical Outcome in Adult B-Cell Acute Lymphoblastic Leukemia: A Real-World Study Based on 486 Patients.

Context.—: Minimal/measurable residual disease (MRD) measured by molecular and multiparametric flow cytometry (MFC) has been proven to be predictive of relapse and survival in patients with B-cell acute lymphoblastic leukemia (B-ALL). A universally applicable antibody panel at a low cost but without compromising sensitivity and power of prognosis prediction in adult B-ALL remains unestablished.

Objective.—: To report our experience of using a single-tube 8-color MFC panel to measure the MRD status as a prognostic indicator in adult B-ALL patients.

Design.—: We retrospectively analyzed the characteristics, MRD status, and prognosis of adult B-ALL based on a large real-world cohort of 486 patients during a 10-year period.

Results.—: MRD assessed by MFC and polymerase chain reaction (PCR) assays for BCR-ABL+ patients showed concordant results in 74.2% of cases. MRD- status by our MFC panel could clearly predict a favorable relapse-free survival (RFS) and overall survival (OS) both at the end of induction and at the end of 1 consolidation course. Patients with continuous MRD- and with at least 1 MRD- result showed a favorable RFS and OS compared with those with at least 1 MRD+ result and continuous MRD+, respectively.

Conclusions.—: The single-tube 8-color MFC panel demonstrated a low cost, decent sensitivity, and comparability with polymerase chain reaction-MRD but an excellent performance in predicting RFS and OS, and thus could potentially be taken as a routine indicator in the evaluation of the treatment response for adult patients with B-ALL.

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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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