CYP1A1常见基因多态性与缺血性卒中风险:荟萃分析和结构检查。

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY Personalized medicine Pub Date : 2023-05-01 DOI:10.2217/pme-2022-0113
Mohammad Karimian, Faezeh Karimnia
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引用次数: 0

摘要

目的:CYP1A1是一种代谢酶,其基因的关键多态性可能与缺血性卒中的风险有关。本研究旨在通过荟萃分析和生物信息学方法探讨CYP1A1基因rs4646903和rs1048943多态性与卒中风险的关系。材料与方法:进行电子检索,经过筛选程序,6项符合条件的研究被纳入meta分析。利用生物信息学工具分析rs4646903和rs1048943对CYP1A1基因功能的影响。结果:rs4646903与缺血性卒中风险降低有显著相关性,而rs1048943与缺血性卒中风险降低无显著相关性。结果表明,rs4646903多态性和rs1048943多态性分别影响基因表达和辅因子亲和力。结论:rs4646903可能是缺血性脑卒中的保护性遗传因子。
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CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination.

Aim: CYP1A1 is a metabolizing enzyme and key polymorphisms in its gene may contribute to the risk of ischemic stroke. This study aimed to investigate the association of the rs4646903 and rs1048943 polymorphisms of CYP1A1 with stroke risk in a meta-analysis and a bioinformatic approach. Materials & methods: An electronic search was conducted and, after the screening procedure, six eligible studies were included in the meta-analysis. Some bioinformatic tools were employed to analyze the effects of rs4646903 and rs1048943 on CYP1A1 gene function. Results: There was a significant association between rs4646903 and the reduced risk of ischemic stroke, whereas there was no significant association for rs1048943. In silico analysis showed that rs4646903 and rs1048943 polymorphisms could affect the gene expression and cofactor affinity, respectively. Conclusion: Based on these results, rs4646903 may be a protective genetic factor against ischemic stroke.

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来源期刊
Personalized medicine
Personalized medicine 医学-药学
CiteScore
3.30
自引率
4.30%
发文量
49
审稿时长
6-12 weeks
期刊介绍: Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.
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