核孔和输入蛋白在单纯疱疹病毒感染中的作用

IF 5.7 2区 医学 Q1 VIROLOGY Current opinion in virology Pub Date : 2023-10-01 DOI:10.1016/j.coviro.2023.101361
Katinka Döhner , Manutea C Serrero , Beate Sodeik
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引用次数: 1

摘要

微管转运和核导入在功能上是相连的,核孔复合体(NPC)可以与微管马达相互作用。对于几种α疱疹病毒蛋白,已经表征了核定位信号(NLS)及其与特定重要蛋白-α的相互作用。在这里,我们回顾了微管马达、衣壳相关NLS和importin-α蛋白在衣壳运输、衣壳与NPC对接和基因组释放到核质中的作用,以及importins在核病毒转录、复制、衣壳组装、基因组包装和核衣壳出口中的作用的最新见解。此外,导入蛋白-α蛋白通过促进诱导干扰素(IFN)、细胞因子和IFN刺激的基因表达的转录因子的核导入而发挥抗病毒作用,并且IFN诱导的MxB限制衣壳与NPC的对接。
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The role of nuclear pores and importins for herpes simplex virus infection

Microtubule transport and nuclear import are functionally connected, and the nuclear pore complex (NPC) can interact with microtubule motors. For several alphaherpesvirus proteins, nuclear localization signals (NLSs) and their interactions with specific importin-α proteins have been characterized. Here, we review recent insights on the roles of microtubule motors, capsid-associated NLSs, and importin-α proteins for capsid transport, capsid docking to NPCs, and genome release into the nucleoplasm, as well as the role of importins for nuclear viral transcription, replication, capsid assembly, genome packaging, and nuclear capsid egress. Moreover, importin-α proteins exert antiviral effects by promoting the nuclear import of transcription factors inducing the expression of interferons (IFN), cytokines, and IFN-stimulated genes, and the IFN-inducible MxB restricts capsid docking to NPCs.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
期刊最新文献
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