Marta Colaneri, Pietro Valsecchi, Sergio G Vancheri, Adele Valentini, Francesca Marchetti, Francesco Tarantino, Margherita Sambo, Massimiliano Fabbiani, Fabrizio Calliada, Vincenzina Monzillo, Angela Di Matteo, Laura Maiocchi, Andrea Lombardi, Catherine Klersy, Lorenzo Preda, Raffaele Bruno
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引用次数: 0
摘要
高分辨率ct扫描(HRCT)在非结核分枝杆菌肺病(NTM-LD)的诊断中发挥重要作用,但其在随访中的作用存在争议。我们的目的首先是设想一个放射学评分,能够量化NTM感染肺部受累的严重程度,其次,检查其与NTM- ld临床负担的关系。如果可能的话,我们还打算验证NTM特异性治疗对放射学评分的潜在影响。回顾性收集2012年1月1日至2020年1月1日确诊为NTM-LD的所有住院患者的临床、微生物学和放射学资料。在诊断时和随访6-18个月时,应用放射学评分评估HRCT肺部受累情况。28例NTM-LD患者行随访HRCT。放射学评分与临床评分无相关性(Spearman R -0.05, 95%CI -0.41 ~ 0.33)。重复测量分析显示放射学评分随时间显著增加(变化1.11,95%CI 0.10至2.11;p值0.032),而Mann-Whitney检验显示治疗组与未治疗组之间无差异(p值0.922)。需要进一步的研究来评估常规放射随访对NTM-LD患者的有效性。
Is a radiological score needed to define the severity of Nontuberculous mycobacteria lung disease?
High-resolution CT-scan (HRCT) plays a major role in the diagnosis of Nontuberculous mycobacteria lung disease (NTM-LD), but its role in follow-up is controversial. Our aim was first to conceive a radiological score able to quantify the severity of pulmonary involvement by NTM infection and, second, to check its association with the NTM-LD clinical burden. We also intended, if possible, to verify the potential influence of NTM specific treatment on the radiological score. We retrospectively collected the clinical, microbiological and radiological data of all patients who were admitted to our hospital from 1 January 2012 to 1 January 2020 with a confirmed diagnosis of NTM-LD. A radiological score was applied to evaluate lung involvement on HRCT at diagnosis and at 6-18 months follow-up. Twenty-eight patients with NTM-LD performed follow-up HRCT. No association was found between radiological and clinical score (Spearman R -0.05, 95%CI -0.41 to 0.33). Repeated measures analysis showed a significant increase in radiological score over time (change 1.11, 95%CI 0.10 to 2.11; p-value 0.032), while Mann-Whitney test did not show any difference between treated and untreated patients (p value 0.922). Further studies are needed to assess the usefulness of routine radiological follow-up in patients with NTM-LD.
期刊介绍:
The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.