CD36有利于脂肪感知和转运，从而控制脂质代谢

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2022-11-01 DOI:10.1016/j.plipres.2022.101193

Yunxia Li , Xingguo Huang , Guan Yang , Kang Xu , Yulong Yin , Gabriele Brecchia , Jie Yin

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引用次数: 10

摘要

CD36位于细胞膜上，对膳食脂肪起转运脂肪酸的作用。它是一种重要的脂肪酸传感器和脂质代谢调节剂。CD36与脂质代谢异常和肥胖之间的相互作用已在各种模型和人体研究中得到证实。然而，CD36调节脂质代谢的机制以及CD36在代谢性疾病中的作用仍不清楚。本文综述了细胞膜CD36在脂肪代谢中的作用的最新研究进展，重点介绍了CD36介导的脂肪感知和转运。这篇综述还批判性地讨论了影响cd36介导的脂肪功能障碍调节的因素。最后，我们回顾了CD36在代谢性疾病中的临床证据，并展望了未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CD36 favours fat sensing and transport to govern lipid metabolism

CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 and lipid dysmetabolism and obesity has been identified in various models and human studies. Nevertheless, the mechanisms by which CD36 regulates lipid metabolism and the role of CD36 in metabolic diseases remain obscure. Here, we summarize the latest research on the role of membrane CD36 in fat metabolism, with emphasis on CD36-mediated fat sensing and transport. This review also critically discusses the factors affecting the regulation of CD36-mediated fat dysfunction. Finally, we review previous clinical evidence of CD36 in metabolic diseases and consider the path forward.

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.