儿童2型糖尿病的表型和病因谱。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Annual review of medicine Pub Date : 2022-01-27 DOI:10.1146/annurev-med-042120-012033
Amy S Shah, Kristen J Nadeau, Dana Dabelea, Maria J Redondo
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引用次数: 11

摘要

包括遗传、家族史、饮食、身体活动、肥胖和青春期胰岛素抵抗在内的几个因素似乎会增加青少年患2型糖尿病的风险。青年发病的2型糖尿病通常被认为是一个单一的实体,而是作为一个疾病谱系存在,在表现、代谢特征、临床进展和并发症发生率方面存在差异。我们回顾了目前已知的与青少年患2型糖尿病相关的风险。此外,我们重点研究了儿童2型糖尿病的表型谱,讨论了这种异质性的致病基础和潜在的治疗相关性,并比较了青年发病的2型糖尿病与1型糖尿病和成人发病的2型糖尿病。最后,我们强调了在预测和预防青少年2型糖尿病方面的知识差距。
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Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children.

Several factors, including genetics, family history, diet, physical activity, obesity, and insulin resistance in puberty, appear to increase the risk of type 2 diabetes in youth. Youth-onset type 2 diabetes is often thought of as a single entity but rather exists as a spectrum of disease with differences in presentation, metabolic characteristics, clinical progression, and complication rates. We review what is currently known regarding the risks associated with developing type 2 diabetes in youth. Additionally, we focus on the spectrum of phenotypes of pediatric type 2 diabetes, discuss the pathogenic underpinnings and potential therapeutic relevance of this heterogeneity, and compare youth-onset type 2 diabetes with type 1 diabetes and adult-onset type 2 diabetes. Finally, we highlight knowledge gaps in prediction and prevention of youth-onset type 2 diabetes.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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