研究芦丁对双酚 A 诱导的大鼠雌性不孕症的作用。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS Combinatorial chemistry & high throughput screening Pub Date : 2025-01-13 DOI:10.2174/1386207326666221226142854
Xiaoqi Yang, Tao Yang, Li Wang, Mengwan Cui, Cong Liu, Zhaorong Wang, Xifeng Cheng
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引用次数: 0

摘要

目的:本研究旨在了解芦丁对暴露于双酚 A(BA)后的大鼠雌性不孕症的影响:背景:如今,不孕症已成为医疗保健系统中的一个主要问题。目前,各种化学物质和毒素暴露在我们的生物系统中。此外,在全球范围内,发展中国家和发达国家的生殖健康改善情况令人担忧。人们对天然药物(如柑橘类水果中提取的植物成分芦丁)的全面了解和完整的治疗范围尚未得到探索。然而,芦丁有助于改善血管健康和平滑肌组织功能:拟议的研究工作旨在探讨芦丁对双酚 A(BA)诱导的大鼠雌性不孕症的作用:BA 是一种强效内分泌干扰物,会导致大鼠雌性不孕。用一氧化氮供体(即硝普钠(SNP))诱导卵母细胞成熟可导致大鼠雌性不孕。在这项研究中,试验化合物芦丁以不同剂量给药,每天 60 分钟,共 21 天:结果:大鼠的雌性不孕症通过雌雄互动行为进行评估,焦虑行为则在 0、7、14 和 21 天进行测试。实验结束后,对雌二醇-17b(E2)、促卵泡激素(FSH)和抗苗勒氏管激素(AMH)、还原型谷胱甘肽(GSH)和脂质过氧化物(MDA)等生物标志物水平进行了评估:结论:芦丁能改善与 BA 相关的女性生殖行为和生物标志物水平。因此,芦丁具有潜在的多靶点作用,如激素调节、抗氧化和抗过氧化作用,可能有助于改善女性生殖健康。
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WITHDRAWN: To Investigate the Role of Rutin on Bisphenol-A Induced Female Infertility in Rats

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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来源期刊
CiteScore
3.10
自引率
5.60%
发文量
327
审稿时长
7.5 months
期刊介绍: Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.
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