细胞因子和细胞因子受体作为免疫介导的炎症性疾病的靶标--以 RA 为榜样。

IF 5 3区医学 Q2 IMMUNOLOGY Inflammation and Regeneration Pub Date : 2022-12-01 DOI:10.1186/s41232-022-00221-x

Tsutomu Takeuchi

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摘要

最近，我们对免疫介导的炎症性疾病（IMID）的认识取得了进展，并通过靶向治疗进行了探索和推广。在这些靶点中，细胞因子和细胞因子受体已成为药物开发的最佳候选靶点。在这篇综述中，综述了在免疫介导的炎症性疾病（IMID）中被批准使用的细胞因子和细胞因子受体，并展示了治疗方式、细胞因子和细胞因子受体在每种疾病中的作用，以及以类风湿性关节炎为例，通过现代技术更新的分子信息，并对未来前景进行了讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases-RA as a role model.

Recent advances in our understanding in the immune-mediated inflammatory diseases (IMID) are explored and promoted by the targeted treatment. Among these targets, cytokines and cytokine receptors have become the good candidates for the drug development. In this review, the cytokine and cytokine receptors, which are approved in IMID, are overviewed, and modalities of the treatment, the role of cytokines and cytokine receptors in each disease, and the updated molecular information by modern technologies in rheumatoid arthritis as a role model are shown and discussed for the future perspectives.

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.