Li-Wei Hung, Heung-Bok Kim, Satoshi Murakami, Goutam Gupta, Chang-Yub Kim, Thomas C Terwilliger
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Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution.
AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.
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