具有 1,2-恶嗪支架的天然产品：出现、化学多样性、生物活性、合成和生物合成

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2023-08-29 DOI:10.1039/D3NP00023K

Li-Hong Yan, Xin Li and Bin-Gui Wang

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引用次数: 0

摘要

覆盖范围：截至 2023 年 7 月底1,2-恶嗪是一种在天然产品中很少发现的杂环支架，其特点是在一个六元环中有一个直接连接的 N-O 键。自 1925 年从卡拉巴尔豆（Physostigma venenosum）中分离出第一个含 1,2-恶嗪的天然产物（1,2-恶嗪 NP）--基因丝氨酸（geneserine）以来，已从不同来源分离和鉴定出 76 种天然存在的 1,2- 恶嗪 NP，引起了天然产物化学、有机合成、生物合成和药理学领域研究人员的关注。本综述概述了 1,2-恶嗪 NPs 的化学家族，重点介绍了它们的来源生物、结构多样性、化学合成和生物合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis

Covering: up to the end of July, 2023

1,2-Oxazine is a heterocyclic scaffold rarely found in natural products and is characterized by a directly connected N–O bond in a six-membered ring. Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Physostigma venenosum) in 1925, a total of 76 naturally occurring 1,2-oxazine NPs have been isolated and identified from various sources, which have attracted the attention of researchers in the field of natural product chemistry, organic synthesis, biosynthesis, and pharmacology. This review summarizes the chemical family of 1,2-oxazine NPs, focusing on their source organisms, structural diversities, chemical synthesis, and biosynthesis.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.