解决艾滋病毒感染者心血管护理方面的差距:衔接科学证据和实践。

IF 4.5 3区 医学 Q2 IMMUNOLOGY Current Opinion in HIV and AIDS Pub Date : 2022-09-01 DOI:10.1097/COH.0000000000000754
Albert Liu, Matthew Feinstein
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引用次数: 0

摘要

综述目的:与一般人群相比,艾滋病毒感染者仍然有心血管疾病的额外负担。造成这些心血管疾病差异的原因包括艾滋病毒特异性风险增强因素、传统的动脉粥样硬化性心血管疾病风险因素和社会人口差异,所有这些都是成熟的干预目标。最近发现:动脉粥样硬化性心血管疾病的准确风险预测仍然很困难,并且在缺乏HIV特异性风险增强因子的情况下,HIV感染者的心血管风险可能被低估。尽管心血管风险增加,但艾滋病毒感染者治疗不足,经常接受不适当的降脂治疗。结构性种族主义和与艾滋病毒有关的耻辱发挥了作用,提供者层面和结构层面的干预措施鼓励早期识别和治疗高危人群是必要的。总结:艾滋病毒感染者应使用现有的心血管风险预测工具进行筛查,高危心血管疾病患者应及时转诊,酌情进行生活方式和药物干预。正在进行系统级实施研究,试图缩小心血管护理方面的差距,特别是在资源匮乏的脆弱社区。
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Addressing gaps in cardiovascular care for people with HIV: bridging scientific evidence and practice.

Purpose of review: People with HIV continue to have an excess burden of cardiovascular disease compared to the general population. The reasons for these disparities in cardiovascular disease include HIV-specific risk enhancers, traditional atherosclerotic cardiovascular disease risk factors, and sociodemographic disparities, all of which are ripe targets for intervention.

Recent findings: Accurate risk prediction of atherosclerotic cardiovascular disease remains difficult, and cardiovascular risk for people with HIV may be underestimated in the absence of HIV-specific risk enhancers. Despite this increased cardiovascular risk, people with HIV are undertreated and often placed on inadequate lipid lowering therapy. Structural racism and HIV-related stigma play a role, and provider-level and structural-level interventions to encourage early identification and treatment of persons at high risk are necessary.

Summary: Persons with HIV should be screened with existing cardiovascular risk prediction tools, and those at high risk cardiovascular disease should be promptly referred for lifestyle and pharmacologic interventions as appropriate. System-level implementation research is ongoing in attempts to narrow the gap in cardiovascular care, particularly for vulnerable communities in low resource settings.

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来源期刊
Current Opinion in HIV and AIDS
Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
7.40
自引率
7.30%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.
期刊最新文献
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV. Anticipating HIV viral escape - resistance to active and passive immunization. Accelerating HIV vaccine development through meaningful engagement of local scientists and communities. Guiding HIV-1 vaccine development with preclinical nonhuman primate research. Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.
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