羟嗪在儿童牙科患者镇静中的安全性。

Taegyeom Kim, Keoungah Kim, Seungoh Kim, Jongbin Kim
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引用次数: 0

摘要

羟嗪是儿童牙科最常用的口服镇静剂之一。本研究旨在调查在儿童牙科中使用羟嗪镇静的安全性和可能的副作用。研究人员使用 Cochrane Library、Embase、PubMed、KISS、KMBASE 和 KoreaMed 数据库检索了 "羟嗪"、"牙科镇静"、"儿童 "和 "安全 "及其相关同义词。此外,还浏览了 DBpia 和 RISS 的学术信息和门户网站。总共找到了 340 篇论文,其中根据详细标准选出了 24 篇论文。9 项研究使用羟嗪作为单一疗法,10 项研究比较了羟嗪作为多种疗法时的安全性。此外,有 7 项研究采用了以羟嗪为成分之一的药物疗法。所有这些研究都表明,使用羟嗪所特有的不良反应是嗜睡和口干,而且由于羟嗪的协同反应,还出现了呼吸系统并发症。尽管羟嗪被归类为组胺受体阻滞剂,但它具有镇静、止吐、抗惊厥和抗胆碱能的特性,是一种口服镇静剂,如果使用剂量适当,并在给药途径中确定其与其他药物的协同作用,则不会出现严重的不良反应。
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Safety of hydroxyzine in the sedation of pediatric dental patients.

Hydroxyzine is one of the most popular oral sedatives used in pediatric dentistry. This study aimed to investigate the safety and possible side effects of sedation using hydroxyzine in pediatric dentistry. "Hydroxyzine," "Dental sedation," "Child," and "Safety" and their associated synonyms were searched using the Cochrane Library, Embase, PubMed, KISS, KMBASE, and KoreaMed databases. Academic information and portals of DBpia and RISS were also perused. Altogether, 340 papers were found, among which a total of 24 papers were selected according to the detailed criteria. Nine studies used hydroxyzine as monotherapy, and 10 studies compared its safety when hydroxyzine used as multitherapy. In addition, seven studies employed a drug regimen wherein hydroxyzine was one of the components. All these studies revealed that the adverse events specific to hydroxyzine usage were drowsiness and dryness of the mouth, and that there were respiratory complications due to a synergistic reaction of hydroxyzine. Although classified as a histamine blocker, hydroxyzine with its sedative, antiemetic, anticonvulsant, and anticholinergic properties is an oral sedative available without serious adverse events, If the proper dosage of the drug is used and its synergistic effects with other drugs are ascertained in the route of administration.

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