Lenacapavir:一流的HIV-1衣壳抑制剂。

IF 4.5 3区 医学 Q2 IMMUNOLOGY Current Opinion in HIV and AIDS Pub Date : 2022-01-01 DOI:10.1097/COH.0000000000000713
Hadas Dvory-Sobol, Naveed Shaik, Christian Callebaut, Martin S Rhee
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引用次数: 34

摘要

综述目的:本综述总结了lenacapavir的现有数据,lenacapavir是一种一流的研究性药物,可在病毒生命周期的多个步骤中破坏HIV衣壳蛋白的功能。最近的发现:Lenacapavir在体外显示出皮摩尔效价,对现有抗逆转录病毒类别没有交叉耐药性,并且在HIV-1患者中具有强大的抗病毒活性。在HIV-1患者中,无论治疗史如何,都没有预先存在对lenacapavir的耐药性。Lenacapavir可每日口服或每周口服,并可每6个月皮下注射一次。在有大量治疗经验的耐多药HIV-1患者和未接受治疗的HIV-1患者中,lenacapavir与其他抗逆转录病毒药物联合使用可导致高病毒学抑制率,并且耐受性良好。总结:正在进行的研究正在评估lenacapavir与其他抗逆转录病毒药物联合治疗HIV-1的长效剂量以及作为单一药物预防HIV-1的效果。
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Lenacapavir: a first-in-class HIV-1 capsid inhibitor.

Purpose of review: This review summarizes available data for lenacapavir, an investigational first-in-class agent that disrupts functioning of HIV capsid protein across multiple steps in the viral life cycle.

Recent findings: Lenacapavir demonstrated picomolar potency in vitro with no cross resistance to existing antiretroviral classes and potent antiviral activity in persons with HIV-1. In persons with HIV-1, there was no preexisting resistance to lenacapavir regardless of treatment history. Lenacapavir can be administered orally either daily or weekly and subcutaneously up to every 6 months. In heavily treatment-experienced persons with multidrug-resistant HIV-1 and in treatment-naive persons with HIV-1, lenacapavir in combination with other antiretroviral agents led to high rates of virologic suppression and was well tolerated.

Summary: Ongoing studies are evaluating long-acting dosing of lenacapavir for treating HIV-1 in combination with other antiretrovirals and preventing HIV-1 as a single agent.

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来源期刊
Current Opinion in HIV and AIDS
Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
7.40
自引率
7.30%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.
期刊最新文献
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV. Anticipating HIV viral escape - resistance to active and passive immunization. Accelerating HIV vaccine development through meaningful engagement of local scientists and communities. Guiding HIV-1 vaccine development with preclinical nonhuman primate research. Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.
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