炎症性肠病中的微生物调节。

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2022-12-01 DOI:10.4110/in.2022.22.e44
Jongwook Yu, Jae Hee Cheon
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引用次数: 0

摘要

肠道生态失调是病因不明的炎症性肠病(IBDs)的显著特征之一。尽管IBD与肠道生态失调之间的因果关系仍有待阐明,但通过调节和纠正肠道生态失调来管理IBD的研究领域已经得到了关注。使用抗生素、益生菌(含或不含益生元)和健康供体的粪便微生物群移植是调节肠道微生物群生态系统的代表性方法。肠道菌群不是细菌、真菌和病毒的简单集合,而是由多种微生物组成的复杂的类器官群落系统。因此,研究肠道微生物群的具体变化取决于所采用的治疗方案是非常有限的。在这里,我们回顾了微生物调节作为IBD治疗选择的既往研究及其在IBD发病机制中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Microbial Modulation in Inflammatory Bowel Diseases.

Gut dysbiosis is one of prominent features in inflammatory bowel diseases (IBDs) which are of an unknown etiology. Although the cause-and-effect relationship between IBD and gut dysbiosis remains to be elucidated, one area of research has focused on the management of IBD by modulating and correcting gut dysbiosis. The use of antibiotics, probiotics either with or without prebiotics, and fecal microbiota transplantation from healthy donors are representative methods for modulating the intestinal microbiota ecosystem. The gut microbiota is not a simple assembly of bacteria, fungi, and viruses, but a complex organ-like community system composed of numerous kinds of microorganisms. Thus, studies on specific changes in the gut microbiota depending on which treatment option is applied are very limited. Here, we review previous studies on microbial modulation as a therapeutic option for IBD and its significance in the pathogenesis of IBD.

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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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