观点:线粒体STAT3在心脏保护中的作用。

IF 7.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Basic Research in Cardiology Pub Date : 2023-08-24 DOI:10.1007/s00395-023-01003-3
Petra Kleinbongard
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引用次数: 0

摘要

激活信号换能器和转录激活因子3 (STAT3)已被确定为一个关键的心脏保护信号,不仅在动物研究中,而且在人类研究中-在动物中,STAT3参与心脏保护。STAT3激活的典型功能上调了心肌保护蛋白和抗凋亡蛋白的表达。在其非规范功能中,STAT3在缺血条件下被激活,是心脏保护性细胞质存活激活因子增强途径的一部分。激活的STAT3被导入并定位于线粒体。线粒体STAT3刺激线粒体电子传递链复合体I的活性,减少线粒体活性氧的产生和线粒体通透性过渡开孔。最后,本文讨论了STAT激活在心脏保护中的两个新方面:STAT编码区域的遗传变异作为心脏保护的潜在原始混杂变量,以及钠-葡萄糖共转运蛋白2抑制剂通过STAT3激活的心脏保护潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Perspective: mitochondrial STAT3 in cardioprotection.

Activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key cardioprotective signal not only in animal studies but also in humans-in animals, STAT3 is causally involved in cardioprotection. In response to late ischemic conditioning, canonical function of STAT3 activation upregulates the expression of cardioprotective and anti-apoptotic proteins. In its non-canonical function, STAT3 is activated during ischemic conditioning and is part of the cardioprotective cytosolic survival activating factor enhancement pathway. Activated STAT3 is imported and localized to the mitochondria. Mitochondrial STAT3 stimulates the activity of mitochondrial electron transport chain complex I, reduces mitochondrial reactive oxygen species production and mitochondrial permeability transition pore opening. Finally, two novel aspects of STAT activation in cardioprotection are discussed: a genetic variance of the STAT encoding region as a potential primordial confounding variable for cardioprotection, and the cardioprotective potential of sodium-glucose cotransporter 2 inhibitors through STAT3 activation.

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来源期刊
Basic Research in Cardiology
Basic Research in Cardiology 医学-心血管系统
CiteScore
16.30
自引率
5.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology
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