cERBB-2/Her-2 Neu在子宫癌肉瘤中的过度表达及其预后意义。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.5146/tjpath.2022.01588
Huseyin Salih Semiz, Emel Ebru Pala, Behzat Can, Elif Atag, Hatice Gungor, Muzaffer Sanci
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摘要

目的:关于子宫癌肉瘤中Her-2的过度表达及其与预后的关系,文献中没有足够的数据。本研究的目的是确定子宫癌肉瘤中Her-2的过表达率,并评估其与预后的关系。材料和方法:分别用免疫组织化学(IHC)和荧光原位杂交(FISH)方法对51例子宫癌肉瘤患者的子宫切除标本中Her-2蛋白和基因状态进行评估。结果:42例患者上皮成分中Her-2蛋白表达呈阴性(33例评分0,9例评分(+1)),7例评分(+2),2例评分(+3)。没有一名患者在肿瘤的肉瘤成分中有Her-2蛋白表达。根据FISH方法,Her-2基因在上皮或间充质肿瘤区域未扩增。Her-2过表达阴性组和阳性组在无病生存期(DFS)和总生存期(OS)方面没有差异。Her-2过表达在65岁或65岁以上诊断的肿瘤患者中显著较高(p=0.046)。结论:在我们的研究中,Her-2过度表达与子宫癌肉瘤的预后之间没有关系。需要更全面的研究来阐明Her-2过表达与癌肉瘤预后之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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cERBB-2/Her-2 Neu Overexpression and Prognostic Significance in Uterine Carcinosarcoma.

Objective: There is not enough data in the literature regarding Her-2 overexpression in uterine carcinosarcomas or its association with the prognosis. The aim of this study was to determine the Her-2 overexpression rate in uterine carcinosarcoma and to evaluate its relationship with the prognosis.

Material and method: Her-2 protein and gene status were evaluated by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively, in hysterectomy specimens from 51 patients with uterine carcinosarcoma.

Results: Her-2 protein expression in the epithelial component was negative in 42 patients (score 0 in 33 cases, score (+1) in 9 cases), score (+2) in 7 patients and score (+3) in 2 patients. None of the patients had Her-2 protein expression within the sarcomatous component of the tumors. Her-2 gene was not amplified in epithelial or mesenchymal tumor areas according to the FISH method. There was no difference between the Her-2 overexpression negative and positive groups in terms of disease-free survival (DFS) and overall survival (OS). Her-2 overexpression was significantly higher in tumors of patients diagnosed at 65 years or older (p=0.046).

Conclusion: In our study, no relationship could be shown between Her-2 overexpression and prognosis in uterine carcinosarcoma. More comprehensive studies are needed to illustrate the relationship between Her-2 overexpression and carcinosarcoma prognosis.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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