乙型肝炎病毒直接抗病毒药物在改善肝纤维化程度方面的疗效评估。

IF 1.5 4区 医学 Q4 IMMUNOLOGY Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-06-01 DOI:10.5114/ceji.2023.127621
Liang Miao, Lihua Cao, Guiqiang Wang
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引用次数: 0

摘要

简介该研究旨在为抗病毒治疗后的患者寻找一种反映炎症和肝纤维化的理想指标,并将其与影像学检查(肝硬度测量-LSM)和传统肝纤维化模型(APRI和FIB-4)进行比较:共纳入77例经恩替卡韦(ETV)治疗后获得持续病毒学应答(SVR)的慢性乙型肝炎(CHB)患者,比较治疗前后各项临床指标的变化:ETV治疗78周后,77例患者的白细胞和凝乳酶原(PLT)显著升高,而谷丙转氨酶(ALT)、谷草转氨酶(AST)和总胆红素显著降低(P<0.05)。血清肌酐(Cr)和血尿素氮(BUN)与治疗前相比无明显差异(P > 0.05)。77例患者的三个非侵入性肝纤维化指数,即LSM、APRI和FIB-4,与治疗前的数值相比明显下降(P < 0.001):结论:声辐射力脉冲(ARFI)、纤维化-4(FIB-4)、天冬氨酸氨基转移酶与血小板比值指数(APRI)与肝纤维化分级具有较高的一致性,可用于评价肝纤维化的严重程度。其中,ARFI 对不同程度的肝纤维化分级具有较好的诊断价值,诊断准确性最好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Efficacy evaluation of direct antiviral drugs against hepatitis B virus in improving the degree of liver fibrosis.

Introduction: The aim of the study was to find an ideal index reflecting inflammation and fibrosis for patients after antiviral treatment, and compare it with imaging examination (liver stiffness measurement - LSM) and traditional liver fibrosis models (APRI and FIB-4).

Material and methods: A total of 77 chronic hepatitis B (CHB) patients who achieved a sustained virological response (SVR) after entecavir (ETV) treatment were included, and the changes of various clinical indicators before and after treatment were compared.

Results: After 78 weeks of ETV treatment, WBC and PLT of 77 patients were significantly increased, while ALT, AST and total bilirubin were significantly decreased (p < 0.05). There was no significant difference in serum creatinine (Cr) or blood urea nitrogen (BUN) compared to the values before treatment (p > 0.05). The three non-invasive liver fibrosis indexes, namely, LSM, APRI and FIB-4, were significantly decreased in 77 patients compared to the values before treatment (p < 0.001).

Conclusions: Acoustic radiation force impulse (ARFI), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI) have a high consistency with the grading of liver fibrosis, and can be used to evaluate the severity of liver fibrosis. Among them, ARFI has good diagnostic value for the classification of different degrees of liver fibrosis and the best diagnostic accuracy.

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来源期刊
CiteScore
3.00
自引率
0.00%
发文量
17
审稿时长
6-12 weeks
期刊介绍: Central European Journal of Immunology is a English-language quarterly aimed mainly at immunologists.
期刊最新文献
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