PTPN21在泛癌分析中的预后价值及免疫学作用。

IF 1.5 4区 医学 Q4 IMMUNOLOGY Central European Journal of Immunology Pub Date : 2023-01-01 DOI:10.5114/ceji.2023.129970
YanE Yang, WenChao Yang, Xingxing Su, CaiXia Cheng
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引用次数: 0

摘要

目前,癌症仍然是全世界面临的一个持久的公共卫生挑战。研究发现,PTPN21与癌症的发展有关。然而,PTPN21在泛癌中的预后潜力尚不清楚。本研究旨在分析PTPN21在泛癌组织中的表达及预后价值,进一步研究PTPN21与免疫浸润的关系。材料和方法:采用TCGA和GEO数据进行表达和生存分析。研究了TCGA癌PTPN21基因的改变。采用TIMER2评价PTPN21表达与免疫浸润的相关性。使用R软件包“ggplot2”和“clusterProfiler”进行GO和KEGG分析。结果:PTPN21在膀胱尿路上皮癌(BLCA)、肾透明细胞癌(KIRC)、肾乳头状细胞癌(KIRP)和肺鳞状细胞癌(LUSC)等多种癌症中具有重要的诊断价值。此外,我们观察到PTPN21的表达与多种肿瘤突变有关。我们的结果表明PTPN21的表达与免疫浸润相关。富集分析表明,PTPN21主要参与神经活性配体-受体相互作用的调节。结论:我们的研究表明PTPN21的表达与临床预后、突变和肿瘤的免疫浸润有关。PTPN21可能是许多癌症的潜在生物标志物,尤其是KIRC。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Prognostic value and immunological role of PTPN21 in pan-cancer analysis.

Introduction: At present, cancer remains a persistent public health challenge facing the whole world. Studies have found that PTPN21 is associated with the development of cancer. However, the prognostic potential of PTPN21 in pan-cancer remains unclear. In this work, we aimed to analyze the expression and prognostic value of PTPN21 in pan-cancer and to further study the relationship between PTPN21 and immune infiltration.

Material and methods: TCGA and GEO data were used for expression and survival analysis. Genetic alterations in PTPN21 from TCGA cancer were studied in cBioPortal. TIMER2 was used to evaluate the correlation between PTPN21 expression and immune infiltration. The R packages "ggplot2" and "clusterProfiler" were used for GO and KEGG analysis.

Results: PTPN21 was found to be a valuable diagnostic biomarker in multiple cancers, including bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and lung squamous cell carcinoma (LUSC). In addition, we observed that PTPN21 expression was associated with a variety of tumor mutations. Our results indicated a correlation between PTPN21 expression and immune infiltration. Enrichment analysis showed that PTPN21 was mainly involved in the regulation of neuroactive ligand-receptor interaction.

Conclusions: Our study showed that PTPN21 expression is associated with clinical prognosis, mutation, and immune infiltration of tumors. PTPN21 may be a potential biomarker for many cancers, especially in KIRC.

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来源期刊
CiteScore
3.00
自引率
0.00%
发文量
17
审稿时长
6-12 weeks
期刊介绍: Central European Journal of Immunology is a English-language quarterly aimed mainly at immunologists.
期刊最新文献
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