Daisy Asiimwe, Isaac Bangi, Jospeh Esanyu, Daniel Ojok, Benedict Okot, Clinton Olong, Robert Wagubi, Godfrey Kisembo, Fred Sempijja, Enoch Muwanguzi, Benson Okongo
{"title":"乌干达Kiryandongo总医院成人消化不良患者幽门螺杆菌感染与贫血的关系","authors":"Daisy Asiimwe, Isaac Bangi, Jospeh Esanyu, Daniel Ojok, Benedict Okot, Clinton Olong, Robert Wagubi, Godfrey Kisembo, Fred Sempijja, Enoch Muwanguzi, Benson Okongo","doi":"10.2147/JBM.S392146","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence of anemia and its association with <i>Helicobacter pylori</i> infection among adult dyspeptic patients.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted among 283 dyspeptic patients at Kiryandongo General Hospital, in Uganda. A structured questionnaire was administered to capture demographic and clinical characteristics of study participants. Four milliliters of blood were then collected into an EDTA vacutainer for Complete Blood Count (CBC) and analyzed using HUMA COUNT 30<sup>TS</sup>, and peripheral blood smears were made and stained using Giemsa stain. Anemia was defined as hemoglobin levels <12g/dl in females and <13g/dl in men according to the World Health Organization (WHO). <i>Helicobacter pylori (H. pylori)</i> stool antigen test was performed using Whole power <i>H. pylori</i> Ag rapid test device, and saline stool preparation was examined for intestinal parasites. Chi-squared test and Logistic regression were performed to determine association, and a p-value of ≤0.05 was considered statistically significant.</p><p><strong>Results: </strong>The overall prevalence of <i>Helicobacter pylori</i> infection was 42.4% (120/283). The prevalence of anemia among <i>H. pylori</i>-infected patients was 25.8% (31/120) and 15.3% (25/163) among <i>H. pylori</i>-negative counterparts. <i>H. pylori</i> infection was significantly associated with anemia (p-value 0.042), age (p-value 0.02, 0.009), water sources (p-value 0.0049,) and intestinal parasitic infestation (p-value 0.02), respectively.</p><p><strong>Conclusion: </strong>This study has shown that the prevalence of <i>H. pylori</i> infection and anemia is high among dyspeptic patients at Kiryandongo General Hospital. <i>H. pylori</i> infection was found associated with anemia, age, water sources, and intestinal parasitic infestation. Routine screening of anemia in <i>H. pylori</i>-infected individuals and further studies to explore the relationship between anemia and <i>H. pylori</i> disease is highly recommended.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"57-66"},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/c8/jbm-14-57.PMC9883989.pdf","citationCount":"1","resultStr":"{\"title\":\"Association Between <i>Helicobacter pylori</i> Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda.\",\"authors\":\"Daisy Asiimwe, Isaac Bangi, Jospeh Esanyu, Daniel Ojok, Benedict Okot, Clinton Olong, Robert Wagubi, Godfrey Kisembo, Fred Sempijja, Enoch Muwanguzi, Benson Okongo\",\"doi\":\"10.2147/JBM.S392146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To determine the prevalence of anemia and its association with <i>Helicobacter pylori</i> infection among adult dyspeptic patients.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted among 283 dyspeptic patients at Kiryandongo General Hospital, in Uganda. A structured questionnaire was administered to capture demographic and clinical characteristics of study participants. Four milliliters of blood were then collected into an EDTA vacutainer for Complete Blood Count (CBC) and analyzed using HUMA COUNT 30<sup>TS</sup>, and peripheral blood smears were made and stained using Giemsa stain. Anemia was defined as hemoglobin levels <12g/dl in females and <13g/dl in men according to the World Health Organization (WHO). <i>Helicobacter pylori (H. pylori)</i> stool antigen test was performed using Whole power <i>H. pylori</i> Ag rapid test device, and saline stool preparation was examined for intestinal parasites. Chi-squared test and Logistic regression were performed to determine association, and a p-value of ≤0.05 was considered statistically significant.</p><p><strong>Results: </strong>The overall prevalence of <i>Helicobacter pylori</i> infection was 42.4% (120/283). The prevalence of anemia among <i>H. pylori</i>-infected patients was 25.8% (31/120) and 15.3% (25/163) among <i>H. pylori</i>-negative counterparts. <i>H. pylori</i> infection was significantly associated with anemia (p-value 0.042), age (p-value 0.02, 0.009), water sources (p-value 0.0049,) and intestinal parasitic infestation (p-value 0.02), respectively.</p><p><strong>Conclusion: </strong>This study has shown that the prevalence of <i>H. pylori</i> infection and anemia is high among dyspeptic patients at Kiryandongo General Hospital. <i>H. pylori</i> infection was found associated with anemia, age, water sources, and intestinal parasitic infestation. Routine screening of anemia in <i>H. pylori</i>-infected individuals and further studies to explore the relationship between anemia and <i>H. pylori</i> disease is highly recommended.</p>\",\"PeriodicalId\":15166,\"journal\":{\"name\":\"Journal of Blood Medicine\",\"volume\":\"14 \",\"pages\":\"57-66\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/c8/jbm-14-57.PMC9883989.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Blood Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/JBM.S392146\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Blood Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/JBM.S392146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Association Between Helicobacter pylori Infection and Anemia Among Adult Dyspeptic Patients Attending Kiryandongo General Hospital, Uganda.
Purpose: To determine the prevalence of anemia and its association with Helicobacter pylori infection among adult dyspeptic patients.
Patients and methods: A cross-sectional study was conducted among 283 dyspeptic patients at Kiryandongo General Hospital, in Uganda. A structured questionnaire was administered to capture demographic and clinical characteristics of study participants. Four milliliters of blood were then collected into an EDTA vacutainer for Complete Blood Count (CBC) and analyzed using HUMA COUNT 30TS, and peripheral blood smears were made and stained using Giemsa stain. Anemia was defined as hemoglobin levels <12g/dl in females and <13g/dl in men according to the World Health Organization (WHO). Helicobacter pylori (H. pylori) stool antigen test was performed using Whole power H. pylori Ag rapid test device, and saline stool preparation was examined for intestinal parasites. Chi-squared test and Logistic regression were performed to determine association, and a p-value of ≤0.05 was considered statistically significant.
Results: The overall prevalence of Helicobacter pylori infection was 42.4% (120/283). The prevalence of anemia among H. pylori-infected patients was 25.8% (31/120) and 15.3% (25/163) among H. pylori-negative counterparts. H. pylori infection was significantly associated with anemia (p-value 0.042), age (p-value 0.02, 0.009), water sources (p-value 0.0049,) and intestinal parasitic infestation (p-value 0.02), respectively.
Conclusion: This study has shown that the prevalence of H. pylori infection and anemia is high among dyspeptic patients at Kiryandongo General Hospital. H. pylori infection was found associated with anemia, age, water sources, and intestinal parasitic infestation. Routine screening of anemia in H. pylori-infected individuals and further studies to explore the relationship between anemia and H. pylori disease is highly recommended.
期刊介绍：
The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine (blood components, stem cell transplantation, apheresis, gene based therapeutics), Blood collection, Donor issues, Transmittable diseases, and Blood banking logistics, Immunohematology, Artificial and alternative blood based therapeutics, Hematology including disorders/pathology related to leukocytes/immunology, red cells, platelets and hemostasis, Biotechnology/nanotechnology of blood related medicine, Legal aspects of blood medicine, Historical perspectives. Original research, short reports, reviews, case reports and commentaries are invited.
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