血管肉瘤伴持续性单侧眼睑肿胀2例。

Pub Date : 2022-02-01 DOI:10.1159/000520293
Shinzo Sakisaka, Mika Tanabe, Shuhei Imayama, Nahoko Zeze, Kanako Yamana, Hiroshi Yoshikawa, Koh-Hei Sonoda
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引用次数: 0

摘要

血管肉瘤是一种众所周知的预后最差的肿瘤;然而,在临床实践中,此类病例很少被眼科医生观察到。这种肿瘤通常长在面部和头皮上,并可能引起眼睑肿胀。我们提出两个这样的案例。病例1是一名82岁的女性,她表现为右眼睑的浸润性肿胀,延伸到前额上部。活检显示边界不清的肿瘤浸润整个真皮和脂肪组织,表现为血管瘤和实性形态。免疫组化示CD31(-)和D2-40/podoplanin(+),提示血管肉瘤。患者有多处肺转移,14个月后死亡。病例2是一名77岁男性,表现为左眼睑肿胀,左侧颞部皮肤红斑形成溃疡结节。活检显示肿瘤细胞呈片状增生,广泛分布于真皮。基于免疫组化:CD31(+), CD34(+)和D2-40(-),血管肉瘤优先。患者接受电子束治疗和化疗,13个月后死亡。对于眼科医生来说,仅仅从眼睑的肿胀就很难怀疑这是一种罕见的肿瘤。然而,如果肿胀从头部皮疹逐渐扩散,附近有结节或溃疡,则应考虑血管肉瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swelling.

Angiosarcoma is a widely known neoplasm with one of the poorest prognoses; however, such cases are rarely observed by the ophthalmologists in clinical practice. The tumor commonly develops on the face and scalp and may cause eyelid swelling. We present 2 such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy revealed a poorly circumscribed tumor infiltrated throughout the dermis and fat tissue, exhibiting both angiomatous and solid patterns. Immunohistochemistry showed CD31(-) and D2-40/podoplanin(+), suggesting angiosarcoma. The patient had multiple lung metastases and died 14 months later. Case 2 was a 77-year-old man who presented with swelling of the left eyelid, and erythema on the left temporal skin developed ulcerated nodules. Biopsy showed proliferated tumor cells in a sheet form, extensively throughout the dermis. Angiosarcoma was preferred based on immunohistochemistry: CD31(+), CD34(+), and D2-40(-). The patient was treated with electron beam therapy and chemotherapy and died after 13 months. It would be difficult for an ophthalmologist to suspect such a rare neoplasm only from swelling of the eyelids. However, angiosarcoma should be considered if the swelling spreads steadily from a head rash with a nodule or ulcer nearby.

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