含Nisin和藏红花素纳米脂质体在牛奶中的应用。

IF 3.1 Q2 PHARMACOLOGY & PHARMACY Advanced pharmaceutical bulletin Pub Date : 2023-01-01 DOI:10.34172/apb.2023.014
Mohammad Yousefi, Seid Mahdi Jafari, Hossein Ahangari, Ali Ehsani
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引用次数: 3

摘要

目的:研究含藏红花素和乳酸链球菌素的纳米脂质体在牛奶样品中的作用。因此,我们制备了三种配方并进行了比较,包括(1)含有游离nisin和藏红花素的牛奶样品,(2)含有nisin和藏红花素的纳米脂质体样品,(3)壳聚糖包被负载nisin和藏红花素的纳米脂质体样品。方法:对纳米脂质体的大小、多分散性指数(PDI)、zeta电位和包封效率进行分析,以确定纳米脂质体中两种生物活性物质的最佳用量。然后,通过抗氧化、抗菌活性、黏度、比色和细菌生长等实验,对最佳配方的纳米脂质体进行了评价,并与游离生物活性溶液和壳聚糖包被纳米脂质体进行了比较。结果:以4 mg藏红花素、4.5 mg乳清素和40 mg卵磷脂为纳米载体,以大小、PDI、zeta电位和包封效率为指标,优选纳米脂质体体系。结果表明,纳米脂质体溶液(a*=5.41)和壳聚糖包被纳米脂质体溶液(a*=5.09)均能显著提高(Pa*=12.32)。然而,壳聚糖包被纳米脂质体溶液中牛奶的粘度(3.42 cP)高于其他配方(游离生物活性样品的粘度为1.65 cP,含纳米脂质体样品的粘度为1.71 cP)。壳聚糖包被纳米脂质体对单核增生李斯特菌生长的抑制作用强于其他样品。结论:用纳米脂质体包封乳酸链球菌素和藏红花素具有良好的食品安全和质量保障效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Application of Nanoliposomes Containing Nisin and Crocin in Milk.

Purpose: This study aimed to investigate the effects of nanoliposomes containing crocin and nisin in milk samples as a food model. Therefore, three formulations were prepared and compared, including (1) milk samples containing free nisin and crocin, (2) samples with nanoliposomes containing nisin and crocin, and (3) nisin and crocin-loaded nanoliposomes coated with chitosan. Methods: In order to find the optimum amount of both bioactives within nanoliposomes, analyses of size, polydispersity index (PDI), zeta potential, and encapsulation efficiency were accomplished. Then, the best formulated nanoliposome was evaluated and compared with a solution containing free bioactives and nanoliposomes coated with chitosan using other experiments, including antioxidant and antibacterial activities, viscosity, colorimetric and bacterial growth. Results: The best nanoliposomal system based on the factors of size, PDI, zeta potential, and encapsulation efficiency was related for the nanocarrier with 4 mg crocin, 4.5 mg nisin, and 40 mg lecithin. Based on the results obtained, both nanoliposome (a*=5.41) and chitosancoated nanoliposome (a*=5.09) solutions could significantly (P<0.05) reduce the redness of milk induced by free bioactives (a*=12.32). However, viscosity of milk in chitosan-coated nanoliposome solution was found to be higher (3.42 cP) than other formulations (viscosity of samples with free bioactives was 1.65 cP and viscosity of samples containing nanoliposome was 1.71 cP). In addition, chitosan-coated nanoliposomes could inhibit the growth of Listeria monocytogenes stronger than other samples. Conclusion: Encapsulation of nisin and crocin in nanoliposomes showed promising results for preserving food safety and quality.

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来源期刊
Advanced pharmaceutical bulletin
Advanced pharmaceutical bulletin PHARMACOLOGY & PHARMACY-
CiteScore
6.80
自引率
2.80%
发文量
51
审稿时长
12 weeks
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