戒烟对早期声门癌患者新的声门癌事件的长期影响。

IF 2.1 4区医学 Q2 OTORHINOLARYNGOLOGY Acta Otorhinolaryngologica Italica Pub Date : 2022-12-01 DOI:10.14639/0392-100X-N1917

Min-Su Kim, Hong-Gyun Wu, Myung-Whun Sung, Tack-Kyun Kwon

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引用次数: 0

摘要

目的:早期声门癌患者有时会在5年后出现新的声门癌事件。本研究旨在分析早期声门癌患者在初始治疗5年后新的声门癌事件的模式和危险因素。方法:本研究共纳入209例患者。回顾性分析患者年龄、性别、T分期、前连关节受累、吸烟方式及治疗方式。结果:中位随访91个月(范围60-266个月)。新声门癌发生的中位时间为97个月(范围61-199个月)。16例(7.6%)患者在初始治疗5年后出现新的声门癌事件，其中12例(75.0%)患者声门癌事件病变与初始病变重叠。治疗后戒烟与5年后新的声门癌发病率显著相关。结论:早期声门癌患者在初始治疗5年后发生新的声门癌事件不可忽视。特别是，如果治疗后继续吸烟，这些患者即使在5年后也可能出现新的声门癌事件。

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Long-term impact of smoking cessation on new glottic cancer events in patients with early glottic cancer.

Objective: Patients with early glottic cancer sometimes exhibit new glottic cancer events after 5 years. This study aimed to analyse the patterns and risk factors of new glottic cancer events in patients with early glottic cancer 5 years after initial treatment.

Methods: In total, 209 patients were included in this study. Age, sex, T stage, anterior commissure involvement, smoking pattern and treatment modality were retrospectively analysed.

Results: The median follow-up was 91 (range, 60-266) months. The median time for the occurrence of new glottic cancer events was 97 (range, 61-199) months. New glottic cancer events occurred 5 years after initial treatment in 16 (7.6%) patients, among whom 12 (75.0%) had new glottic cancer event lesions overlapping with initial lesions. Smoking cessation after treatment was significantly correlated with fewer new glottic cancer events after 5 years.

Conclusions: New glottic cancer events occurring 5 years after initial treatment in patients with early glottic cancer are not negligible. In particular, if smoking is continued after treatment, these patients can experience new glottic cancer events even after 5 years.

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来源期刊

Acta Otorhinolaryngologica Italica OTORHINOLARYNGOLOGY-

CiteScore

3.40

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini. It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.). The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief. Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.