3d打印非共面模板辅助ct引导下碘125粒子近距离植入治疗腹股沟淋巴结转移癌剂量学参数的比较研究

IF 1.1 4区 医学 Q4 ONCOLOGY Journal of Contemporary Brachytherapy Pub Date : 2022-10-01 DOI:10.5114/jcb.2022.121564
Yanhao Liu, Zongyan Shen, Ang Qu, Ping Jiang, Yuliang Jiang, Junjie Wang
{"title":"3d打印非共面模板辅助ct引导下碘125粒子近距离植入治疗腹股沟淋巴结转移癌剂量学参数的比较研究","authors":"Yanhao Liu,&nbsp;Zongyan Shen,&nbsp;Ang Qu,&nbsp;Ping Jiang,&nbsp;Yuliang Jiang,&nbsp;Junjie Wang","doi":"10.5114/jcb.2022.121564","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To compare the pre-plan and post-plan dosimetric parameter differences of 3D-printed non-coplanar templates (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 (<sup>125</sup>I) radioactive seed implantation brachytherapy (RISI) in patients with inguinal lymph node metastasis (ILNM).</p><p><strong>Material and methods: </strong>This was a retrospective study of 15 patients with ILNM carcinomas treated with 3D-PNCT-assisted CT-guided RISI between May, 2015 and April, 2018. All patients underwent prior external beam radiotherapy (EBRT) or surgery. Dosimetric parameters included D<sub>90</sub>, D<sub>100</sub> (dose delivered to 90% and 100% of the volume, respectively), V<sub>100</sub>, V<sub>150</sub>, V<sub>200</sub> (percentage of target volume receiving 100%, 150%, and 200% of the prescribed dose, respectively). Quality parameters included conformal index (CI), external index (EI), and homogeneity index (HI). Paired <i>t</i>-test and Bland-Altman analysis were applied to compared pre-plan and post-plan parameters.</p><p><strong>Results: </strong>The median gross tumor volume (GTV) in the pre-plan was 8.7 ml (range, 0.8-185.1 ml). There were statistically significant differences in V<sub>100</sub>, V<sub>150</sub>, CI, and EI (<i>p</i> < 0.05). Bland-Altman analysis indicated that accidental error of RISI was small. In 1 of the 15 cases, D<sub>90</sub> and D<sub>100</sub> exceeded the prescribed therapeutic accuracy. In 1 of the 15 cases, V<sub>150</sub>, EI, and GTV were outside the specified accuracy range (95% confidence interval).</p><p><strong>Conclusions: </strong>3D-PNCT-assisted CT-guided RISI is a safe, accurate, and feasible choice in ILNM treatment. The procedure of RISI has significantly improved. The pre-plan can be accurately executed by 3D-PNCT-assisted CT-guided RISI.</p>","PeriodicalId":51305,"journal":{"name":"Journal of Contemporary Brachytherapy","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/66/JCB-14-48290.PMC9720692.pdf","citationCount":"1","resultStr":"{\"title\":\"A comparative study of dosimetric parameters of 3D-printed non-coplanar template-assisted CT-guided iodine-125 seed implantation brachytherapy in patients with inguinal lymph node metastatic carcinomas.\",\"authors\":\"Yanhao Liu,&nbsp;Zongyan Shen,&nbsp;Ang Qu,&nbsp;Ping Jiang,&nbsp;Yuliang Jiang,&nbsp;Junjie Wang\",\"doi\":\"10.5114/jcb.2022.121564\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To compare the pre-plan and post-plan dosimetric parameter differences of 3D-printed non-coplanar templates (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 (<sup>125</sup>I) radioactive seed implantation brachytherapy (RISI) in patients with inguinal lymph node metastasis (ILNM).</p><p><strong>Material and methods: </strong>This was a retrospective study of 15 patients with ILNM carcinomas treated with 3D-PNCT-assisted CT-guided RISI between May, 2015 and April, 2018. All patients underwent prior external beam radiotherapy (EBRT) or surgery. Dosimetric parameters included D<sub>90</sub>, D<sub>100</sub> (dose delivered to 90% and 100% of the volume, respectively), V<sub>100</sub>, V<sub>150</sub>, V<sub>200</sub> (percentage of target volume receiving 100%, 150%, and 200% of the prescribed dose, respectively). Quality parameters included conformal index (CI), external index (EI), and homogeneity index (HI). Paired <i>t</i>-test and Bland-Altman analysis were applied to compared pre-plan and post-plan parameters.</p><p><strong>Results: </strong>The median gross tumor volume (GTV) in the pre-plan was 8.7 ml (range, 0.8-185.1 ml). There were statistically significant differences in V<sub>100</sub>, V<sub>150</sub>, CI, and EI (<i>p</i> < 0.05). Bland-Altman analysis indicated that accidental error of RISI was small. In 1 of the 15 cases, D<sub>90</sub> and D<sub>100</sub> exceeded the prescribed therapeutic accuracy. In 1 of the 15 cases, V<sub>150</sub>, EI, and GTV were outside the specified accuracy range (95% confidence interval).</p><p><strong>Conclusions: </strong>3D-PNCT-assisted CT-guided RISI is a safe, accurate, and feasible choice in ILNM treatment. The procedure of RISI has significantly improved. The pre-plan can be accurately executed by 3D-PNCT-assisted CT-guided RISI.</p>\",\"PeriodicalId\":51305,\"journal\":{\"name\":\"Journal of Contemporary Brachytherapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/66/JCB-14-48290.PMC9720692.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Contemporary Brachytherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/jcb.2022.121564\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Contemporary Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/jcb.2022.121564","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 1

摘要

目的:比较3d打印非共面模板(3D-PNCT)辅助计算机断层扫描(CT)引导碘-125 (125I)放射性粒子植入近距离放射治疗(RISI)治疗腹股沟淋巴结转移(ILNM)患者的术前和术后剂量学参数差异。材料和方法:本研究是一项回顾性研究,2015年5月至2018年4月,15例il - nm癌患者接受3d - pnct辅助ct引导的RISI治疗。所有患者均接受过体外放射治疗(EBRT)或手术。剂量学参数包括D90、D100(分别达到体积的90%和100%的剂量)、V100、V150、V200(分别达到规定剂量的100%、150%和200%的靶体积百分比)。质量参数包括保形指数(CI)、外部指数(EI)和均匀性指数(HI)。采用配对t检验和Bland-Altman分析比较计划前后参数。结果:术前总肿瘤体积(GTV)中位数为8.7 ml(范围0.8 ~ 185.1 ml)。V100、V150、CI、EI差异有统计学意义(p < 0.05)。Bland-Altman分析表明,RISI的意外误差较小。15例中有1例D90和D100超过了规定的治疗准确性。15例中有1例的V150、EI和GTV在规定的准确度范围(95%置信区间)之外。结论:3d - pnct辅助ct引导下的RISI治疗ILNM是一种安全、准确、可行的选择。RISI的程序有了明显的改进。3d - pnct辅助ct引导下的RISI可以准确执行预先计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A comparative study of dosimetric parameters of 3D-printed non-coplanar template-assisted CT-guided iodine-125 seed implantation brachytherapy in patients with inguinal lymph node metastatic carcinomas.

Purpose: To compare the pre-plan and post-plan dosimetric parameter differences of 3D-printed non-coplanar templates (3D-PNCT)-assisted computed tomography (CT)-guided iodine-125 (125I) radioactive seed implantation brachytherapy (RISI) in patients with inguinal lymph node metastasis (ILNM).

Material and methods: This was a retrospective study of 15 patients with ILNM carcinomas treated with 3D-PNCT-assisted CT-guided RISI between May, 2015 and April, 2018. All patients underwent prior external beam radiotherapy (EBRT) or surgery. Dosimetric parameters included D90, D100 (dose delivered to 90% and 100% of the volume, respectively), V100, V150, V200 (percentage of target volume receiving 100%, 150%, and 200% of the prescribed dose, respectively). Quality parameters included conformal index (CI), external index (EI), and homogeneity index (HI). Paired t-test and Bland-Altman analysis were applied to compared pre-plan and post-plan parameters.

Results: The median gross tumor volume (GTV) in the pre-plan was 8.7 ml (range, 0.8-185.1 ml). There were statistically significant differences in V100, V150, CI, and EI (p < 0.05). Bland-Altman analysis indicated that accidental error of RISI was small. In 1 of the 15 cases, D90 and D100 exceeded the prescribed therapeutic accuracy. In 1 of the 15 cases, V150, EI, and GTV were outside the specified accuracy range (95% confidence interval).

Conclusions: 3D-PNCT-assisted CT-guided RISI is a safe, accurate, and feasible choice in ILNM treatment. The procedure of RISI has significantly improved. The pre-plan can be accurately executed by 3D-PNCT-assisted CT-guided RISI.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
期刊最新文献
The role of EUS-guided iodine-125 seed implantation in patients with unresectable ampullary cancer after relief of obstructive jaundice Acute toxicity outcomes from salvage high-dose-rate brachytherapy for locally recurrent prostate cancer after prior radiotherapy Differential outcomes of re-stratified high-risk prostate cancer patients treated with external beam radiation therapy plus high-dose-rate brachytherapy boost A unified strategy to focal brachytherapy incorporating transperineal biopsy, image fusion, and real-time implantation with and without rectal spacer simulated in prostate phantoms Post-operative complications following dose adaptation of intra-operative electron beam radiation therapy in locally advanced or recurrent rectal cancer
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1