Blanca González-Bermúdez, Aldo Abarca-Ortega, Mónica González-Sánchez, Mónica De la Fuente, Gustavo R Plaza
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引用次数: 0
摘要
衰老与免疫衰老的发展相互关联。本文将重点关注适应性免疫系统的细胞组之一--T 细胞,并对已知的与衰老相关的 T 细胞变化进行综述。这种根本性的变化会影响细胞的分子含量和内部排序。然而,要完整描述这些层面的变化,需要对参数进行大量测量,而且内部排序的重要细节可能难以检测到。因此,细胞表征的另一种方法是对整个细胞进行物理测量,如变形性测量或迁移测量:物理参数与常用的化学生物标记互为补充,有助于更好地了解老化过程中 T 细胞状态的演变。机械测量与其他生物物理测量一样,具有相对简单的优点:一个单一参数就能凝集细胞老化过程中逐渐出现的各种变化的复杂影响。
Possibilities of using T-cell biophysical biomarkers of ageing.
Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal ordering. However, acquiring a complete description of the changes at these levels would require extensive measurements of parameters and, furthermore, important fine details of the internal ordering that may be difficult to detect. Therefore, an alternative approach for the characterisation of cells consists of the performance of physical measurements of the whole cell, such as deformability measurements or migration measurements: the physical parameters, complementing the commonly used chemical biomarkers, may contribute to a better understanding of the evolution of T-cell states during ageing. Mechanical measurements, among other biophysical measurements, have the advantage of their relative simplicity: one single parameter agglutinates the complex effects of the variety of changes that gradually appear in cells during ageing.
期刊介绍:
Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.