禽呼肠孤病毒变异的分子特征及其与抗原性和致病性的关系

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES Avian Diseases Pub Date : 2022-12-01 DOI:10.1637/aviandiseases-D-22-99995
Rodrigo A Gallardo
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引用次数: 3

摘要

禽呼肠孤病毒变异(ARVs)是目前造成家禽生产损失的重要病原体。这些变异逃避了传统疫苗(即鸡的S1133、2408和1733)所产生的保护作用。历史上,抗逆转录病毒药物根据其抗原类型和相对致病性进行分类。由于病毒的变异性,抗原检测是困难的和实验室特异性的,而病理分型是昂贵和复杂的。目前的分子分类方法只关注一个基因,该基因内的基因组变化并不能预测抗原性和致病性的变化。本文综述了呼肠孤病毒抗原性、致病性和分子评估方面的现有文献,以期为如何基于基因组信息预测抗原性和致病性表型以及未来发展新的综合分类系统提供见解。
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Molecular Characterization of Variant Avian Reoviruses and Their Relationship with Antigenicity and Pathogenicity.

Avian reovirus variants (ARVs) are important pathogens currently causing losses in poultry production. These variants escape protection elicited by conventional vaccines, i.e., S1133, 2408, and 1733 in chickens. Historically, ARVs have been classified according to their antigenic type and relative pathogenicity. Due to the virus variability, antigenic testing is difficult and laboratory specific, while pathotyping is costly and complex. Current molecular classification methods focus only on one gene, and genomic changes within this gene are not predictive of changes in antigenicity and pathogenicity. This review focuses on existing literature on reovirus antigenicity, pathogenicity, and molecular assessments as an aid to provide insights on how to predict antigenic and pathogenic phenotypes based on genomic information and future focus on development of new and comprehensive classification systems.

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来源期刊
Avian Diseases
Avian Diseases 农林科学-兽医学
CiteScore
2.40
自引率
7.10%
发文量
80
审稿时长
3 months
期刊介绍: Avian Diseases is an international journal dedicated to publishing original basic or clinical research of the highest quality from various disciplines including microbiology, immunology, pathology and epidemiology. Papers on avian diseases relevant to etiology, pathogenesis, diagnosis, treatment, and control are accepted. Manuscripts dealing with avian species other than poultry will be considered only if the subject is relevant to poultry health.
期刊最新文献
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