整合素连接激酶(ILK)及其在肝脏病理生物学中的作用。

Q2 Biochemistry, Genetics and Molecular Biology Gene expression Pub Date : 2021-06-11 DOI:10.3727/105221621X16113475275710

Nicole Martucci, George K Michalopoulos, Wendy M Mars

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引用次数: 8

摘要

整合素连接激酶(Integrin linked kinase, ILK)是一种重要的信号蛋白，在全身普遍表达。它与细胞内整合素结合，帮助促进与细胞粘附、凋亡、增殖、迁移和大量其他常见细胞功能相关的信号传导。本文就ILKs在肝脏中的作用作一综述。研究表明，ILK是肝脏ECM组织、肝脏再生、胰岛素抵抗和肝细胞癌的主要参与者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.

Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.

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来源期刊

Gene expression 生物-生物工程与应用微生物

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.