炎症在组织修复和再生中的独特作用

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-01-31 DOI:10.1007/s12272-023-01428-3
Bokeum Choi, Changjun Lee, Je-Wook Yu
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引用次数: 1

摘要

炎症是机体应对微生物感染和组织损伤的重要防御机制。除了在感染中的作用外,炎症还积极参与组织损伤后受损组织的修复和体内平衡状态的恢复。炎症反应的强度和参与炎症的细胞类型对组织修复的质量有重要影响。许多免疫细胞亚型参与组织修复和再生。特别是,免疫细胞源性分泌物,包括细胞因子和生长因子,可以主动调节常驻干细胞或祖细胞的增殖,促进组织再生。这些发现强调了炎症在组织修复和再生中的重要性;然而,免疫细胞在组织再生中的确切作用仍不清楚。在这篇综述中,我们总结了目前关于特定免疫细胞类型对组织修复和再生的贡献的知识。我们还讨论了炎症如何影响组织再生的最终结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Distinctive role of inflammation in tissue repair and regeneration

Inflammation is an essential host defense mechanism in response to microbial infection and tissue injury. In addition to its well-established role in infection, inflammation is actively involved in the repair of damaged tissues and restoration of homeostatic conditions after tissue injury. The intensity of the inflammatory response and types of cells involved in inflammation have a significant impact on the quality of tissue repair. Numerous immune cell subtypes participate in tissue repair and regeneration. In particular, immune cell-derived secretants, including cytokines and growth factors, can actively modulate the proliferation of resident stem cells or progenitor cells to facilitate tissue regeneration. These findings highlight the importance of inflammation during tissue repair and regeneration; however, the precise role of immune cells in tissue regeneration remains unclear. In this review, we summarize the current knowledge on the contribution of specific immune cell types to tissue repair and regeneration. We also discuss how inflammation affects the final outcome of tissue regeneration.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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