在颌面部骨折患者中,对比特立帕肽与四裂叶松和Dalbergia Sissoo复方制剂对骨愈合的影响:一项随机开放标签对照试验。

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Craniomaxillofacial Trauma & Reconstruction Pub Date : 2023-03-01 Epub Date: 2022-01-19 DOI:10.1177/19433875211067007
Gigi Pg, Ankita Chugh, Kirti Chaudhry, Amanjot Kaur, Pravin Kumar, Shubham Gaur, Shailendra Kumar, Surjit Singh
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引用次数: 0

摘要

研究设计随机对照试验:与对照组相比,皮下注射特立帕肽和复方片剂(Cissus Quadrangularis和Dalbergia sissoo的复方制剂)是否能改善颌面部骨折愈合。方法:将24名下颌骨骨折患者随机分为3组(对照组1、复方片剂2和注射特立帕肽3),治疗时间为4周。术前和术后定期评估疼痛、骨折部位活动度、咬合力、血清标志物和影像学愈合情况,直至 12 周:结果:第 2 组早期疼痛缓解,但不明显。第 3 组在所有时间点均显示出最高的前咬合力。在第 8 周和第 12 周,平均后咬合力(PBF)的变化在组间比较中显示出统计学意义上的显著增加;然而,在第 12 周,第 3 组明显优于第 1 组,与其他组相比,第 1 组的后咬合力最高。血清钙和 PTH 水平无明显差异,而血清 ALP 在第 3 组有明显增加:两组干预药物在加速骨折愈合和改善咬合力恢复方面均显示出良好的骨合成作用;然而,第 3 组的早期影像学愈合和血清成骨标志物的增加表明其在颌面部骨折愈合中可能发挥乐观作用。
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Comparison of Teriparatide and Combination of Cissus Quadrangularis and Dalbergia Sissoo on Bone Healing Against the Control Group in Maxillofacial Fractures: A Randomized Open-label Control Trial.

Study design: Randomized Control Trial.

Objective: A randomized control trial was planned to aim to assess whether subcutaneous Injection of Teriparatide and Tablet Reunion (combination of Cissus Quadrangularis and Dalbergia sissoo) improves maxillofacial fracture healing as compared to the control group.

Methods: 24 patients of mandibular fracture with or without concomitant maxillofacial fractures were randomly divided into 3 equal groups (Group 1- Control, Group 2- Tablet Reunion, and Group 3- Injection Teriparatide) and the treatment duration was 4 weeks. Pain, fracture site mobility, bite force, serum markers, and radiographic healing were assessed preoperatively and postoperatively at regular intervals till 12 weeks.

Results: Group 2 showed early pain relief, although it was insignificant. Group 3 showed the highest anterior bite force at all the time points. Change in mean posterior bite force (PBF) showed a statistically significant increase at 8th week and 12th week in intergroup comparison; however, at 12th week, Group 3 was significantly better than Group 1 and reported the highest posterior bite force compared to other groups. Serum calcium and PTH level showed no significant difference, whereas Serum ALP showed a statistically significant increase in Group 3. The radiographic assessment showed no significant difference among the 3 groups.

Conclusions: Both the intervention group drugs showed a promising effect on accelerating the fracture healing and improving bite force restoration with the osteoanabolic action; however, early radiographic healing and increased serum osteogenic markers in Group 3 indicate its possible optimistic role in maxillofacial fracture healing.

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Craniomaxillofacial Trauma & Reconstruction
Craniomaxillofacial Trauma & Reconstruction DENTISTRY, ORAL SURGERY & MEDICINE-
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