严重急性呼吸系统综合征冠状病毒感染者的 IgM 和 IgG 抗体与血液特征的相关性。

Q2 Medicine Clinical and Molecular Allergy Pub Date : 2022-12-22 DOI:10.1186/s12948-022-00180-1

Zahra Alibolandi, Amirreza Ostadian, Saeed Sayyah, Hamed Haddad Kashani, Hassan Ehteram, Hamid Reza Banafshe, Mohammad Hajijafari, Mahdi Sepehrnejad, Narjes Riahi Kashani, Mohammd-Javad Azadchehr, Hossein Nikzad, Elahe Seyed Hosseini

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引用次数: 0

摘要

研究目的本研究旨在确定不同病情严重程度的 2019 年冠状病毒病（COVID-19）患者对严重急性呼吸系统综合征冠状病毒（SARS-CoV）-2 的 IgM 和 IgG 抗体反应水平：通过酶联免疫吸附试验（ELISA）评估IgM和IgG抗体水平。本研究共纳入 100 名确诊感染 SARS-CoV-2 的患者，采用实时 PCR 技术检测病毒 RNA。收集并分析了 COVID-19 入院后和入院后两个月的临床和实验室数据：结果：入院 2 个月后，重症患者的抗 SARS-CoV-2 抗体 IgG 水平明显高于中度和轻度患者。此外，入院后重症组的 IgG 水平与白细胞、NUT 和 LYM 计数的增加呈正相关：我们的研究结果表明，重症患者接触病毒的时间更长，对病毒感染的抗体反应更强。结论：我们的研究结果表明，重症患者接触病毒的时间可能更长，对病毒感染的抗体反应更强，因此，与其他组别相比，他们的免疫时间更长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The correlation between IgM and IgG antibodies with blood profile in patients infected with severe acute respiratory syndrome coronavirus.

Objectives: This study aimed to determine the levels of IgM and IgG antibody response to the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with different disease severity.

Methods: IgM and IgG antibody levels were evaluated via enzyme-linked immunosorbent assay (ELISA). In total, 100 patients with confirmed SARS-CoV-2 infection were enrolled in this study and viral RNA was detected by using Real-time PCR technique. Clinical and laboratory data were collected and analyzed after hospital admission for COVID-19 and two months post-admission.

Results: The level of anti-SARS-CoV-2 antibody IgG was significantly higher in the severe patients than those in moderate and mild groups, 2 months after admission. Also, level of IgG was positively associated with increased WBC, NUT and LYM counts in sever than mild or moderate groups after admission to hospital.

Conclusion: Our findings suggested that patients with severe illness might experience longer virus exposure times and have a stronger antibody response against viral infection. Thus, they have longer time immunity compared with other groups.

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.