COVID-19感染对胎盘功能的影响。

IF 1.2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Ginekologia polska Pub Date : 2023-01-01 DOI:10.5603/GP.a2022.0139
Izabela Pilarska, Magdalena Bizon, Wlodzimierz Sawicki
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引用次数: 3

摘要

目的:孕妇免疫功能天然抑制,易患传染病。SARS-CoV-2似乎对妇女和胎儿的状况有潜在的风险。不幸的是,关于冠状病毒病19 (COVID-19)对孕妇及其子女的影响的了解仍然非常有限,需要进一步调查和分析。该研究的目的是对COVID-19对胎盘影响的研究进行荟萃分析。材料和方法:对PubMed和Elsevier数据库中收录的2020 - 2021年间发表的文章进行分析。结果:SARS-CoV-2感染也导致患者出现妊娠并发症。最常见的妊娠并发症包括剖腹产(80%)、早产(26%)、胎儿窘迫(8%)、胎膜早破(9%)和死产(2%)。在观察到的患者中,出现了新生儿并发症,如早产(25%)、呼吸窘迫综合征(8%)、肺炎(8%)和4例新生儿死亡。SARS-CoV-2主要出现在胎盘母胎边界的合体滋养细胞中。胎盘组织学检查显示大量巨噬细胞浸润。观察到胎儿血管灌注异常或胎儿血管血栓形成。在9名新生儿脐带血中观察到SARS-CoV-2 IgG或IgM抗体水平升高,报告为垂直感染的证据。结论:新冠肺炎患者胎盘损伤特征与对照组明显不同。需要进一步的研究来更好地了解SARS-CoV-2感染如何影响胎盘。
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Influence of COVID-19 infection on placental function.

Objectives: Pregnant women are more susceptible to infectious diseases because of their natural immunosuppression. SARS-CoV-2 seems to be a potential risk for the condition of women and the fetus. Unfortunately, knowledge of the influence of coronavirus disease 19 (COVID-19) on pregnant women and their children is still very limited, and further investigation and analysis are needed. The aim of the study was to conduct a meta-analysis of research about the impact of COVID-19 on the placenta.

Material and methods: Articles published between 2020 and 2021 and contained in the PubMed and Elsevier databases were analyzed.

Results: The SARS-CoV-2 infection also led to pregnancy complications in the patients. The most common pregnancy complications include caesarean delivery (80%), preterm delivery (26%), fetal distress (8%), premature rupture of the membranes (9%) and stillbirth (2%). Among the observed patients, neonatal complications occurred, such as premature delivery (25%), respiratory distress syndrome (8%), pneumonia (8%) and deaths of 4 newborns SARS-CoV-2 was found mainly in syncytiotrophoblast cells at the maternal-fetal border of the placenta. Histological examination of the placenta revealed dense macrophage infiltration. Abnormal perfusion of fetal blood vessels or fetal vascular thrombosis was observed. Elevated levels of SARS-CoV-2 IgG or IgM antibodies in the umbilical cord blood were observed in nine newborns, reported as evidence of vertical infection.

Conclusions: The features of placental damage in women with COVID-19 are clearly different from the control group. Further research is needed to better understand how SARS-CoV-2 infection affects the placenta.

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来源期刊
Ginekologia polska
Ginekologia polska OBSTETRICS & GYNECOLOGY-
CiteScore
2.00
自引率
15.40%
发文量
317
审稿时长
4-8 weeks
期刊介绍: Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.
期刊最新文献
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