{"title":"转录调控蛋白sty4289对伤寒沙门氏菌ct18抑制作用的同源模拟分析","authors":"Anila Farid, Saadia Sadiq, Rehana Rasool, Ghazala Rasool, Ajmal Hussain, Muhammad Fawad","doi":"10.55519/JAMC-01-11032","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Salmonella typhi cause typhoid fever which is life threatening disease. It affects approximately 600,000 people per annum around the world. Food and water are the integral components through which this disease is transmitted and becomes base of typhoid. It spreads widely where cleanliness is very poor. Objective was to analyse three-dimensional structure of transcriptional regulator of Salmonella typhi CT18 by homology modelling to inhibit virulent effect of Salmonella typhi.</p><p><strong>Methods: </strong>Bioinformatics tools and programs like comprehensive Microbial resource (CMR). Interproscan, Basic Local Alignment Search tool (BLAST), Modeller 9.10, Procheck and Prosa were used as bioinformatic tools for effective study of protein.</p><p><strong>Results: </strong>Homology modelling is an appropriate and precise method to find three-dimensional transcriptional regulator to stop its virulency.</p><p><strong>Conclusions: </strong>Homology modelling is computational and accurate method to find 3D structure of transcriptional regulator to inhibit its virulence effect of causing disease.</p>","PeriodicalId":15141,"journal":{"name":"Journal of Ayub Medical College, Abbottabad : JAMC","volume":"35 1","pages":"17-20"},"PeriodicalIF":0.0000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis Of Inhibitory Effect Of Transcriptional Regulatory Protein (Sty 4289) Of Salmonella Typhi Ct18by Homology Modelling.\",\"authors\":\"Anila Farid, Saadia Sadiq, Rehana Rasool, Ghazala Rasool, Ajmal Hussain, Muhammad Fawad\",\"doi\":\"10.55519/JAMC-01-11032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Salmonella typhi cause typhoid fever which is life threatening disease. It affects approximately 600,000 people per annum around the world. Food and water are the integral components through which this disease is transmitted and becomes base of typhoid. It spreads widely where cleanliness is very poor. Objective was to analyse three-dimensional structure of transcriptional regulator of Salmonella typhi CT18 by homology modelling to inhibit virulent effect of Salmonella typhi.</p><p><strong>Methods: </strong>Bioinformatics tools and programs like comprehensive Microbial resource (CMR). Interproscan, Basic Local Alignment Search tool (BLAST), Modeller 9.10, Procheck and Prosa were used as bioinformatic tools for effective study of protein.</p><p><strong>Results: </strong>Homology modelling is an appropriate and precise method to find three-dimensional transcriptional regulator to stop its virulency.</p><p><strong>Conclusions: </strong>Homology modelling is computational and accurate method to find 3D structure of transcriptional regulator to inhibit its virulence effect of causing disease.</p>\",\"PeriodicalId\":15141,\"journal\":{\"name\":\"Journal of Ayub Medical College, Abbottabad : JAMC\",\"volume\":\"35 1\",\"pages\":\"17-20\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Ayub Medical College, Abbottabad : JAMC\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.55519/JAMC-01-11032\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ayub Medical College, Abbottabad : JAMC","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55519/JAMC-01-11032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景:伤寒沙门氏菌引起的伤寒是一种危及生命的疾病。它每年影响全世界大约60万人。食物和水是这种疾病传播的组成部分，并成为伤寒的基础。它在清洁程度很差的地方广泛传播。目的通过同源性建模分析伤寒沙门菌CT18转录调控因子的三维结构，以抑制伤寒沙门菌的毒力作用。方法:综合微生物资源(CMR)等生物信息学工具和程序。利用Interproscan、Basic Local Alignment Search tool (BLAST)、modelmodel9.10、Procheck和Prosa等生物信息学工具对蛋白质进行有效研究。结果:同源性建模是寻找三维转录调控因子以阻止其毒力的一种合适而精确的方法。结论:同源性建模是发现转录调控因子三维结构以抑制其致病毒力作用的精确计算方法。
Analysis Of Inhibitory Effect Of Transcriptional Regulatory Protein (Sty 4289) Of Salmonella Typhi Ct18by Homology Modelling.
Background: Salmonella typhi cause typhoid fever which is life threatening disease. It affects approximately 600,000 people per annum around the world. Food and water are the integral components through which this disease is transmitted and becomes base of typhoid. It spreads widely where cleanliness is very poor. Objective was to analyse three-dimensional structure of transcriptional regulator of Salmonella typhi CT18 by homology modelling to inhibit virulent effect of Salmonella typhi.
Methods: Bioinformatics tools and programs like comprehensive Microbial resource (CMR). Interproscan, Basic Local Alignment Search tool (BLAST), Modeller 9.10, Procheck and Prosa were used as bioinformatic tools for effective study of protein.
Results: Homology modelling is an appropriate and precise method to find three-dimensional transcriptional regulator to stop its virulency.
Conclusions: Homology modelling is computational and accurate method to find 3D structure of transcriptional regulator to inhibit its virulence effect of causing disease.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
