脑组织中的代谢补充。

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2023-02-10 DOI:10.1146/annurev-physiol-021422-091035
L F Barros, I Ruminot, T Sotelo-Hitschfeld, R Lerchundi, I Fernández-Moncada
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引用次数: 10

摘要

信息处理对神经元施加了迫切的代谢需求,而神经元的能量储存微不足道,获取燃料的途径也有限。在这里,我们讨论代谢募集,即活跃神经元从周围环境中获取资源的组织水平现象。主要事件是神经元释放K+,这反映了工作量。星形胶质细胞由于其独特的NBCe1和α2β2 Na+/K+ atp酶的共同表达,以精致的方式感知K+,并在几秒钟内切换到Crabtree代谢,包括GLUT1,有氧糖酶解,线粒体呼吸的短暂抑制和乳酸输出。乳酸激增通过抑制远端细胞的葡萄糖消耗而起到二次招募作用。另外的招聘者是谷氨酸、一氧化氮和铵,它们在不同的时空域中发出信号。这些活动的最终结果是产生更多的葡萄糖、乳酸和氧气。代谢招募与神经血管耦合和各种平均策略一起工作,以支持单个神经元的不平衡动态范围。
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Metabolic Recruitment in Brain Tissue.

Information processing imposes urgent metabolic demands on neurons, which have negligible energy stores and restricted access to fuel. Here, we discuss metabolic recruitment, the tissue-level phenomenon whereby active neurons harvest resources from their surroundings. The primary event is the neuronal release of K+ that mirrors workload. Astrocytes sense K+ in exquisite fashion thanks to their unique coexpression of NBCe1 and α2β2 Na+/K+ ATPase, and within seconds switch to Crabtree metabolism, involving GLUT1, aerobic glycolysis, transient suppression of mitochondrial respiration, and lactate export. The lactate surge serves as a secondary recruiter by inhibiting glucose consumption in distant cells. Additional recruiters are glutamate, nitric oxide, and ammonium, which signal over different spatiotemporal domains. The net outcome of these events is that more glucose, lactate, and oxygen are made available. Metabolic recruitment works alongside neurovascular coupling and various averaging strategies to support the inordinate dynamic range of individual neurons.

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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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