他汀类药物对COVID-19合并糖尿病患者呼吸系统症状和肺纤维化的影响:一项纵向多中心研究

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2023-02-28 DOI:10.1007/s00005-023-00672-1
Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Tania Dehesh, Nima Taefehshokr, Adel Sadeghdoust, Katarzyna Kotfis, Amirhossein Hashemiattar, Amir Ravandi, Neda Aligolighasemabadi, Omid Vakili, Beniamin Grabarek, Rafał Staszkiewicz, Marek J. Łos, Pooneh Mokarram, Saeid Ghavami
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引用次数: 0

摘要

本前瞻性队列研究的目的是探讨他汀类药物对2019冠状病毒病(COVID-19)合并糖尿病(DM)患者长期呼吸道症状和肺纤维化的影响。从三家三级医院招募患者,将其分为他汀类药物组和非他汀类药物组,并在症状出现后第0、28和90天进行评估,记录症状持续时间。通过高分辨率计算机断层扫描在基线和随访时间点对肺纤维化进行评分。倾向评分匹配后,每组176例。数据分析显示,在随访期间,非他汀类药物组咳嗽和呼吸困难的几率明显高于他汀类药物组。总体而言,两组间肺纤维化评分变化无显著差异。然而,与他汀类药物组相比,非他汀类药物5年糖尿病患者在随访期间更有可能表现出明显更高的纤维化评分。我们的研究结果表明,他汀类药物的使用与糖尿病合并COVID-19患者发生慢性咳嗽和呼吸困难的风险较低相关,并可能减少长期(5年)dm患者与COVID-19相关的肺纤维化
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Effects of Statins on Respiratory Symptoms and Pulmonary Fibrosis in COVID-19 Patients with Diabetes Mellitus: A Longitudinal Multicenter Study

The aim of this prospective cohort study was to explore the effect of statins on long-term respiratory symptoms and pulmonary fibrosis in coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM). Patients were recruited from three tertiary hospitals, categorized into Statin or Non-statin groups, and assessed on days 0, 28, and 90 after symptoms onset to record the duration of symptoms. Pulmonary fibrosis was scored at baseline and follow-up time points by high-resolution computed tomography scans. Each group comprised 176 patients after propensity score matching. Data analysis revealed that the odds of having cough and dyspnea were significantly higher in the Non-statin group compared to the Statin group during the follow-up period. Overall, there was no significant difference in the change in pulmonary fibrosis score between groups. However, Non-statin patients with > 5 years of DM were more likely to exhibit a significantly higher fibrosis score during the follow-up period as compared to their peers in the Statin group. Our results suggest that the use of statins is associated with a lower risk of developing chronic cough and dyspnea in diabetic patients with COVID-19, and may reduce pulmonary fibrosis associated with COVID-19 in patients with long-term (> 5 years) DM.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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